The FDA authorized Abraxane® in October 2012 for the purpose of managing non-small cell lung cancer (NSCLC), the most common form of lung cancer [220]. The albumin-bound PTX NPs had an average particle size of 130 nm. Since the composition of these nanoparticles fully removes Cremophor ...
The main strategies for this purpose are conjugation of proteins or other small molecules to albumin by a chemical link, or gene fusion, in which the gene for a protein is joined to that of albumin and expressed from a suitable expression host, forming a single polypeptide (Sleep et al., ...
(1963) assumed a pK of 11 for tyrosyl hydroxyl groups and calculated that for the purpose of comparison the association constant of transferrin is about 1036. This constant cannot, however, be directly compared with other association constants because of the involvement of HCO3– in the complex....
PhaseStatusPurposeConditionsCountStart DateWhy Stopped100+ additional columns Not Available Active Not Recruiting Not Available Decompensated Cirrhosis 1 somestatus stop reason just information to hide Not Available Active Not Recruiting Treatment Brain Injury / Coronary Heart Disease (CHD) / Kidney Failure...
Purpose: Cytosolic delivery of nanobodies for molecular target binding and fluorescent labeling in living cells. Methods: Fluorescently labeled nanobodies ... R Röder,J Helma,T Preiß,... - 《Pharmaceutical Research》 被引量: 6发表: 2017年 AGuIX nanoparticle-nanobody bioconjugates to target...
The purpose of this ... N Fletcher,L Gilbertson,R Bruce,... - 《Spine Deformity》 被引量: 0发表: 2021年 1477: IMPACT OF INITIAL OVERRESUSCITATION ON SURVIVAL IN CRITICALLY ILL SURGICAL SUBJECTS Introduction/Hypothesis: Conventional clinical assessments of intravascular blood volume (BV) as a ...
PurposeMesenchymal stem cells (MSC) with biomaterials have osteoinductive potential. The aim of this study was to evaluate early bone formation in xenogeni... A Wildburger,M Payer,N Jakse,... - 《Clinical Oral Implants Research》 被引量: 17发表: 2014年 Amniotic membrane as part of a skin...
The seminal use of fatty acids for this purpose was myristoylatedinsulin detemir(Levemir®, Novo Nordisk, Denmark), which was approved by the FDA in 2005. Insulin is a 5.8kDapolypeptideconsisting of two chains linked by threedisulfides. In Levemir®, the polypeptide is myristoylated at the ...
body mass indexmortalityPURPOSE: The purpose of this retrospective descriptive study was to investigate if body mass index (BMI) and serum albumin (SA) impacted mortality rates in adult African-American patients on hemodialysis (HD). DATA SOURCES: Records of 204 patients on HD (N = 204) from...
NanoparticlesActive agentPurposeOutcomeReferences HSA-coated polymeric nanoparticles Quercetin Release modification crystal-induced Inflammation Prolonged release of quercetin inhibition of crystal (oxalate)-induced cell death [136] BSA-modified polyethylenimine nanoparticles Quinacrine Inhalability against nonsmall ce...