2024年3月21日,同济大学、复旦大学及安徽科技大学等多单位合作,周兆才、赵世民及Shi Jiao共同通讯在Journal of clinical Investigation在线发表题为“The alanyl-tRNA synthetase AARS1 moonlights as a lactyltransferase to promote YAP signa...
4月22日,苏州大学周芳芳团队在国际顶刊Cell上在线发表了题为“Alanyl-tRNA synthetase, AARS1, is a lactate sensor and lactyltransferase that lactylates p53 and contributes to tumorigenesis”的最新科研成果。该研究首先发现肿瘤来源的乳酸是p53的天然抑制因子,可促进p53的乳酸化;进一步鉴定到细胞内的乳酸传感器和...
2024年4月22日，苏州大学生物医学研究院周芳芳团队在在线发表题为“Alanyl-tRNA synthetase, AARS1, is a lactate sensor and lactyltransferase that lactylates p53 and contributes to tumorigenesis”的研究论文，这是苏州大学首次以第一单位在上发表研究成果。该研究AARS1作为乳酸传感器介导肿瘤细胞中的全局赖氨酸乳...
AARS1 mutations are frequently responsible for autosomal dominant Charcot-Marie-Tooth disease type 2N (CMT2N).Objective To identify pathogenic mutation in the Korean patients with CMT and distal hereditary motor neuronopathy (dHMN).Methods We screened AARS1 mutations in 373 unrelated CMT families ...
alanyl-tRNA synthetase 基因家族 Aminoacyl tRNA synthetases, Class II alanyl-tRNA synthetase 基因家族内其他分子相关蛋白和抗体试剂 官方名通用名产品类型 (点击查看)官方全称别称 AARS2AARS2AARS2alanine tRNA ligase 2, mitochondrial, bA444E17.1, KIAA1270 ...
求助补充材料,Alanyl-tRNA synthetase, AARS1, is a lactate sensor and lactyltransferase that lactylates p53 and contributes to tumorigenesis本帖完毕 如果您觉得本站好用,欢迎不吝分享: 回帖 提交评论 等待你,消灭零评论我的文献求助列表 发布帖子 一分钟了解求助规则 | 捐赠本站 | 历史今天 ...
4月22日,苏州大学周芳芳团队在国际顶刊Cell上在线发表了题为“Alanyl-tRNA synthetase, AARS1, is a lactate sensor and lactyltransferase that lactylates p53 and contributes to tumorigenesis”的最新科研成果。该研究首先发现肿瘤来源的乳酸是p53的天然抑制因子,可促进p53的乳酸化;进一步鉴定到细胞内的乳酸传感器和...
MP28-04ALANYL-TRNA SYNTHETASE (AARS1) ACTS AS A LACTATE SENSOR AND LACTATE TRANSFERASE THAT BINDS TO P53 AND INHIBITS METASTASIS AND DRUG TOLERANCE IN RENAL CANCERdoi:10.1097/01.JU.0001110068.14710.ff.04Xiaolin ChenKan GongWolters KluwerThe Journal of Urology...
To test such variants for dominant-negative properties, we developed a humanized yeast assay to co-express pathogenic human alanyl-tRNA synthetase (AARS1) mutations with wild-type human AARS1. We show that multiple loss-of-function AARS1 mutations impair yeast growth through an interaction with ...
AARS2Cerebellar ataxiaLeukoencephalopathyOvarioleukodystrophyRecessive ataxiaMutations in the mitochondrial alanyl-tRNA synthetase gene, AARS2, have been reported to cause leukoencephalopathy associated with early ovarian failure, a clinical presentation described as "ovarioleukodystrophy." We present a sibling ...