Normalization of Alanine Aminotransferase Levels at the End of Treatment with Direct-Acting Antiviral Therapy for Chronic Hepatitis C Infection Is Associated with Sustained Virological Response: 803Naravadi, Vishnu Vardhan ReddyGonzalez, BeverlyCotler, Scott...
(DOCX 38 kb) Abbreviations ALT: alanine aminotransferase; ATAHC: Australian trial in acute hepatitis C; HCV: hepatitis C virus; IFN: interferon-gamma; IL: interleukin; IP-10: interferon- gamma inducible protein-10; IQR: inter-quartile range; MCP: monocyte chemotactic protein; MIP: macrophage ...
The evaluation tools include direct fibrosis‐related serum markers (eg, BioFibroScore, Fibrotest, Enhanced Liver Fibrosis [ELF] test, etc),3, 4 or a calculation from relevant indirect blood markers (eg, aspartate aminotransferase [AST] to platelet ratio index [APRI], or fibrosis‐4 [FIB‐4...
There are two known alanine-glyoxylateaminotransferase(AGXT) (seeGlossary)isoenzymesin mammals: AGXT1 andAGXT2[1], both of which catalyze the transfer of an amino group fromalaninetoglyoxylate(Figure 1A). AGXT1 has been extensively characterized owing to its role in thedetoxification...
(AlaAT) gene family in poplar seedlings Zhiru Xu1,2, Jing Ma2, Chunpu Qu1,3,Yanbo Hu2, Bingqing Hao1,Yan Sun1, Zhongye Liu1, Han Yang1, Chengjun Yang3, Hongwei Wang2,Ying Li4 & Guanjun Liu1,3 Alanine aminotransferase (AlaAT, E.C.2.6.1.2) catalyzes...
synthesized two fluorinated, conformationally restrained GABA analogues as potential GABA aminotransferase inhibitors. all-cis Hydroxylated γ-aminocyclohexanecarboxylic acid derivatives (±)-526 and (±)-532 were obtained by catalytic hydrogenation of the aromatic precursors followed by protection steps, and...
Hepatitis B virus (HBV) DNA levels of patients with normal or mildly elevated alanine aminotransferase (ALT) at each time point (*p < 0.05) Full size image Fig. 3 The trend of hepatitis B surface antigen (HBsAg) levels in patients with normal or mildly elevated alanine aminotransferase ...
We find that expression of alanine aminotransferases is increased in the liver in mice with obesity and diabetes, as well as in humans with type 2 diabetes. Hepatocyte-selective silencing of both alanine aminotransferase enzymes in mice with obesity and diabetes retards hyperglycaemia and reverses ...
Background and Aims: Hepatitis C virus (HCV) infection results in hepatocytic injury with elevation of both alanine aminotransferase (ALT) and aspartate aminotransferase (AST). It remains to be determined if direct-acting antiviral treatment can terminat
Here we present evidence of complete X-ray induced reduction of the internal aldimine double bond in the enzyme alanine:glyoxylate aminotransferase major allele (AGT-Ma; EC 2.6.1.44). By coupling this result with the crystal structure at different pH of the AGT pathogenic variant D183N, bearing...