Trehalose can delay postmenopausal osteoporosis in rats, which may be achieved by inducing and enhancing Akt/TFEB pathway-dependent autophagy flow.doi:10.3892/etm.2023.12237YONGLI WANGXINGCUN LIHONGLIANG GAOIAN LUExperimental & Therapeutic Medicine
例如,Akt/Rheb的激活可以使中枢神经系统的轴突再生,并且在PD病人的脑组织中,Akt的表达和磷酸化水平明显降低。对Akt作用机理的研究证实,Akt可以通过磷酸化多种凋亡相关蛋白来抑制细胞凋亡。但Akt信号通路对氧化应激诱导的神经细胞凋亡有何影响目前尚不清楚。 TFEB(transcription factor EB),是亮氨酸拉链bHLH-Zip转录因子...
et al. mTORC1-independent TFEB activation via Akt inhibition promotes cellular clearance in neurodegenerative storage diseases. Nat. Commun. 8, 14338 (2017).Palmieri, M.; Pal, R.; Nelvagal, H.R.; Lotfi, P.; Stinnett, G.R.; Seymour, M.L.; Chaudhury, A.; Bajaj, L.; Bondar, V.V...
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The mechanism is partly due to improved lysosome function that correlates with enhanced TFEB nuclear translocation and GSK3β activity inhibition. Since PI3K/Akt is a well-recognized signaling pathway of HGF as well as in the pathogenesis of DN, we suggest that PI3K-GSK3β-TFEB axis could be ...
DOI: 10.1038/ncomms15793 OPEN Corrigendum: mTORC1-independent TFEB activation via Akt inhibition promotes cellular clearance in neurodegenerative storage diseases Michela Palmieri, Rituraj Pal, Hemanth R. Nelvagal, Parisa Lotfi, Gary R. Stinnett, Michelle L. Seymour, Arindam Chaudhury, Lakshya Bajaj,...
Palmieri M, Pal R, Sardiello M. AKT modulates the autophagy- lysosome pathway via TFEB. Cell Cycle. 2017;16:1237-8.Palmieri M, Pal R, Sardiello M. AKT modulates the autophagy-lysosome pathway via TFEB. Cell Cycle. 2017;16(13):1237-8....
The activation of TFEB by AS I was impeded upon the introduction of the mammalian target of rapamycin (mTOR) agonist MHY1485. The inhibition of p-mTOR by AS I and the activation of TFEB were no longer observed after administration of the Akt agonist SC-79, which indicated that AS I ...
These results suggested that HGF protected against diabetic nephropathy through restoring podocyte autophagy, which at least partially involved PI3K/Akt-GSK3 beta TFEB axis-mediated lysosomal function improvement.Hou, BoLi, YankunLi, XueZhang, CongyingZhao, ZhonghuaChen, QiZhang, NongLi, Hui...
Here, we find that increased AKT2 inhibits PGC-1伪 to downregulate SIRT5, which we identify as an AKT2 binding partner. Crosstalk between SIRT5 and AKT2 facilitates TFEB-dependent lysosomal function in the RPE. AKT2/SIRT5/TFEB pathway inhibition in the RPE induced lysosome/autophagy signaling...