The ubiquitous PI3K/Akt pathway regulates proliferation, apoptosis and differentiation by controlling a broad range of target proteins including NF-kappa B and GSK-3 beta. The roles of the PI3K/Akt/ NF-kappa B and PI3K/Akt/GSK-3 beta pathways in CPB-related lung injury are unclear.关键词:...
We isolated mouse bone marrow-derived macrophages (BMDMs), detected effect of modafinil on the viability and proliferation of BMDMs, and on oxidized low-density lipoprotein-induced IL-6 and TNF-alpha, and supernatant level of IFN-gamma as well as NF-kappa B activity in BMDMs. Modafinil ...
我们的发现提供了有力的证据,即在体外和体内,抑制NMMHC II(很可能是NMMHC IIA)都会通过Akt / GSK3 beta-NF-kappa B信号通路抑制IF表达和静脉血栓形成。 NMMHC IIA可能是治疗血栓形成疾病的潜在新靶标。 著录项 来源 《Thrombosis and Haemostasis: Journal of the International Society on Thrombosis and ...
Abstract 4109: EphrinA2 promotes tumorigenicity through Rac1\\/Akt\\/NF-kappa B signaling pathway in liver cancer Liver cancer: EphrinA2 promotes tumorigenicity through Rac1/Akt/NF-kappaB signaling pathway 120. Hepatology. 2010; 51 :535–544. doi: 10.1002/hep.23313... Feng,Yu-xiong,Zhao,....
CONCLUSION: Ethyl acetate fraction flavonoid anthill has antitumor activity in multiple molecular targets transduction pathway including Akt and nuclear factor-kappa B (NF-B) squamous cell carcinoma of the tongue. 展开 关键词: Akt signal transduction SP-C1 cells anthill plants nuclear factor-kappa B ...
MED27 promotes melanoma growth by targeting AKT/MAPK and NF-kappa B/iNOS signaling pathways 来自 万方 喜欢 0 阅读量: 32 作者:Tang,Ranran,Xiangdong,Yang,Wenjing,Wendan,Shuai,Xuan,Yang,Tang,Zhipeng,Zhao,Shilei,Chen,Yiming,Xiao,Xiangsheng,Huang,Wenlin,Deng,Wuguo ...
NMMHC IIA inhibition impedes tissue factor expression and venous thrombosis via Akt/GSK3 beta-NF-kappa B signalling pathways in the endothelium 喜欢 0 阅读量: 42 作者:Zhang,Yuanyuan,Zhai,Kefeng,Yu,Jun,Kou,Junping,Li,Fang 摘要: Non-muscle myosin heavy chain IIA (NMMHC IIA) has 关键词:...
Luteolin and luteolin-7-O-glucoside inhibit lipopolysaccharide-induced inflammatory responses through modulation of NF-κB/AP-1/PI3K-Akt signaling cascades... Song, "Luteolin and luteolin-7-O-glucoside inhibit lipopolysaccharide- induced inflammatory responses through modulation of NF- kappa B/AP-1/...
Keywords: repetitive low-level blast;Akt/NF-κB signaling pathway;macrophage polarization;early apoptosis;inhibitor;immune homeostasis
(B,D) indicate the quantitative plots of the percentage of MFI of nucleus vs. cytoplasm ratio, which signifies a decrease in translocation of p-Nf-κB (p65) expression compared to DMSO (vehicle control (VC) in both the cell lines. MBZ substantially exerts its anticancer effects on OVCAR3 ...