We discovered that britanin inhibits the growth of prostate cancer cells both in vitro and in vivo by regulating PI3K/Akt/NF- kappa B-related proteins and activating immunity. These findings shed light on the development of britanin as a promising agent for prostate cancer therapy. 展开 ...
Fig. 4. AGP inhibits calcification of hVICs via interfering Akt, ERK1/2, NF-κB activation. (A) Protein expression profiles of phosphorylated ERK, IκBα and AKT under the OM (osteogenic medium) conditioned culturing with or without AGP, (B) Statistical analysis of p/t-AKT (phospho-AKT/...
我们的发现提供了有力的证据,即在体外和体内,抑制NMMHC II(很可能是NMMHC IIA)都会通过Akt / GSK3 beta-NF-kappa B信号通路抑制IF表达和静脉血栓形成。 NMMHC IIA可能是治疗血栓形成疾病的潜在新靶标。 著录项 来源 《Thrombosis and Haemostasis: Journal of the International Society on Thrombosis and ...
Downregulation of DNA-PKcs suppresses P-gp expression via inhibition of the Akt/NF-κB pathway in CD133-positive osteosarcoma MG-63 cells Ka, Li,Xin,etc.Downregulation of DNA-PKcs suppresses P-gp expression via inhibition of the Akt/NF-κB pathway in CD133-positive osteosarcoma MG-63 ... ...
Luteolin and luteolin-7-O-glucoside inhibit lipopolysaccharide-induced inflammatory responses through modulation of NF- kappa B/AP-1/PI3K-Akt signaling cas... S. Song, "Luteolin and luteolin-7-O-glucoside inhibit lipopolysaccharide-induced inflammatory responses through modulation of NF-kappaB/Ap-1/PI...
Ginkgolide A inhibits lipopolysaccharide-induced inflammatory response in human coronary artery endothelial cells via downregulation of TLR4-NF-kappa B sig... Ginkgolide A inhibits lipopolysaccharide-induced inflammatory response in human coronary artery endothelial cells via downregulation of TLR4-NF-κB signa...
and cholinergic system but can also be effective against cognitive behavioral disorders caused by the consumption of alcohol through suppression of the AKT and NF-κB pathways. In addition, up-regulated neuroplasticity and BBB function were attributed to the ameliorating effects of FPB on neuroapoptosi...
Nutrients 2022, 14(14), 2877; https://doi.org/10.3390/nu14142877 ActionDateNotesLink article pdf uploaded. 13 July 2022 15:08 CEST Version of Record https://www.mdpi.com/2072-6643/14/14/2877/pdf-vor article xml file uploaded 15 July 2022 06:03 CEST Original file - article xml uploade...
Mon significantly inhibited the expression of TRAF6, phosphorylation of P65, and degradation of IKBα, thus inhibiting the activation of NF-κB pathway in LPS-induced inflammatory mice and OCs derived from BMMs, and also inhibited LPS-induced phosphorylation of protein kinase B (Akt) and Glycogen ...