为了研究 mTORC1 是否通过调节细胞脂质代谢来调节铁死亡,作者检查了脂质合成的中心调节因子SREBP1,它被证明是 mTORC1 活性的下游靶标。在多种类型的 RSL3 抗性癌细胞中,mTORC1 抑制剂 CCI-779 能降低成熟形式的 SREBP1 (SREBP1m) 的...
The PI3K-Akt-mTOR-SREBP1 pathway was found to be involved in the regulation of SCD1 expression and lung fibroblast activation.#The data obtained in this study indicate that SCD1 expression contributes to fibroblast activation and airway remodeling and that the inhibition of SCD1 may be a ...
There are comments on PubPeer for publication: Down-Regulation of SREBP via PI3K/AKT/mTOR Pathway Inhibits the Proliferation and Invasion of Non-Small-Cell Lung Cancer Cells (2020)
霄笑萧萧 算是一个认真生活的人 随笔-脂代谢异常和癌症 | 一、脂代谢异常:癌症的“代谢燃料库”能量与物质供应癌细胞通过脂肪酸从头合成(FASN酶催化)大量生成脂质,构建细胞膜并满足能量需求。抑制FASN可显著减少肝癌细胞转移能力。信号通路驱动PI3K/Akt/mTOR通路:激活后促进固醇调节元件结合蛋白(SREBP)释放,上调脂质合...
We show here that activation of SREBP and Akt-dependent induction of lipid biosynthesis requires the activity of mTORC1. Furthermore, activation of SREBP contributes to Akt-dependent cell growth in mammalian cells in vitro and in Drosophila melanogaster in vivo. Our data demonstrate the importance ...
胰岛素信号通路也会影响细胞生长和有丝分裂,主要是通过Akt级联进行,也会有Ras/MAPK通路的参与。另外,胰岛素信号通路可以通过中断CREB/CBP/Torc2的结合抑制肝脏中的糖异生。胰岛素信号通路还可以通过激活SREBP-1C,USF1和LXR来促进脂肪酸的合成。从Akt/PKB,PKCζ,p70 S6K和MAPK级联得到的负反馈信息会导致丝氨酸的磷酸...
通过将PI3K-AKT-mTOR通路抑制剂和铁死亡诱导剂组合使用用于小鼠体内的实验证实,抑制该通路会增加癌细胞对铁死亡的敏感性,抑制小鼠肿瘤的发展,可增强癌症的治疗效果。 结论1:PI3K-AKT-mTOR信号通路→调控→SREBP1高表达;SREBP1→介导→脂生成→→促进→铁死亡抵抗。
Taken together, our work demonstrated that the induction of ferroptosis contributed to the PI3Kδ inhibitor-induced cell death via the suppression of AKT/mTOR/SREBP1-mediated lipogenesis, thus displaying a promising therapeutic effect of TYM-3–98 in CRC treatment....
p-AKTPKM2p-mTORSREBP-1cFatty acid synthase (FASN) catalyzing the terminal steps in the de novo biogenesis of fatty acids is correlated with low survival and high disease recurrence in patients with bladder cancer. Pyruvate kinase M2 (PKM2) regulates the final step of glycolysis levels and ...
Further study in porcine mammary epithelial cells (PMECs) confirmed that valine upregulated the phosphorylation levels of AKT-activated MTOR and subsequently induced the nuclear accumulation of sterol regulatory element binding protein 1 (SREBP1), thus increasing the expression of proteins related to ...