AKT and PRAS40 are components of the PI3K pathway. This pathway plays a role in glucose uptake, cell growth and apoptosis inhibition. The precise function of PRAS40 is not yet known, however, it has been hypothesized that PRAS40 interacts with SH3 and WW ...
The PI3K/AKT pathway is activated by the production of 3’-phosphorylated phosphoinositides (Fig.1), and it is an important signaling pathway for MDR in a variety of cancers, such as breast cancer, leukemia, lung cancer, ovarian cancer, hepatocellular carcinoma, and melanoma7,8,9,10,11,12....
AKT and PRAS40 are components of the PI3K pathway. This path 35、way plays a role in glucose uptake, cell growth, and apoptosis inhibition. The precise function of PRAS40 is not yet known; however, it has been hypothesized that PRAS40 interacts with SH3 and WW domain containing proteins,...
Upstream activation of the PI3K/Akt signaling pathway is essential for its function in cancer and other related diseases. Activation of this pathway is related to many factors, including the RTK family, Toll-like receptors (TLRs), and B-cell antigen receptors (BCRs). Major upstream components o...
database was used to analyze the GO function and KEGG pathway; The phosphorylation of PI3K/AKT in the colonic mucosal was detected with Western blotting. Results PA significantly alleviated colitis in TNBS-treated mice as shown by improvements in the DAI, body weight loss, colon length, and ...
[152]by serving as a direct downstream mediator of poly (ADP-ribose) polymerase-1 (PARP1), a key regulatoryenzymefor repairing DNA[153]. Additionally, impaired mitochondrial function and increased hepatic fat accumulation were also observed after pharmacological inhibition of the Akt pathway in high...
[4] Millis SZ, Ikeda S, Reddy S, Gatalica Z, Kurzrock R. Landscape of Phosphatidylinositol-3-Kinase Pathway Alterations Across 19 784 Diverse Solid Tumors. JAMA Oncol. 2016;2(12):1565-1573. [5] Mery B, Poulard C, Le Romancer M, Trédan O. Targeting AKT in ER-Positive HER2-Negat...
8. Anastasaki, C., Longman, D., Capper, A., Patton, E.E., and Ca´ ceres, J.F. (2011). DHX34 and NBAS function in the NMD pathway and are required for embryonic development in zebrafish.Nucleic Acids Res.39, 3686-3694. ...
genes while downregulating osteogenic gene expression at both mRNA and protein levels. Mechanistic studies revealed that FGF9, through FGFR1, promoted adipogenic gene expression via PI3K/AKT/Hippo pathways and inhibited osteogeni...
function increases SOX9 protein levels, increasing the malignancy of cancer and resistance to cisplatin [35]. As a major oncoprotein inhibitor, once FBW7 is deleted or mutated, it can cause tumors to occur directly [36,37]. So targeted inhibition of the PI3K pathway has a bright therapeutic ...