NF-kappa BCELL growthNEOVASCULARIZATIONACUTE myeloid leukemiaCHRONIC myeloid leukemiaAPOPTOSISThe article focuses on the role of Akt/NF-κB inhibitor xanthohumol in cell growth and angiogenesis in hematologic malignancies based on a study in Italy. The study investigated the in vitro activity o...
Akt在调节NF-kappa-b依赖基因转录中起着重要作用,并对CREB1(环AMP(cAMP)-反应元件结合蛋白)的活性起到积极的调节作用。Creb1的磷酸化诱导了bcl2和mcl1等促生存基因转录所必需的辅助蛋白的结合。Akt在ATP柠檬酸裂合酶(acly)上磷酸化“ser-454”,从而潜在地调节acly活性和脂肪酸合成。通过“ser-273”的磷酸化激活...
AKT)和核因子κB(nuclear factor kappa B,NF-κB)信号通路在温和气单胞菌诱导宿主细胞炎性应答中的作用及相关的分子机制,并分别从正反向进行了研究,围绕NF-κB、MAPK、磷酯酰肌醇-3-激酶(phosphatidylinositol 3 kinase,PI3K)/AKT等...
NF-κB及ICAM-1在非小细胞肺癌中的表达及其临床意义 目的探讨核因子NF-κ B(nuclearfactor of kappa B,NF-κ B)及细胞间粘附分子-1(intercellular adhesionmolecule-1,ICAM-1)在非小细胞肺癌(non-small cell lung cancer... 曾旭,罗百灵 - 《中国现代医学杂志》 被引量: 21发表: 2005年 TLR4与NF-κB...
The ubiquitous PI3K/Akt pathway regulates proliferation, apoptosis and differentiation by controlling a broad range of target proteins including NF-kappa B and GSK-3 beta. The roles of the PI3K/Akt/ NF-kappa B and PI3K/Akt/GSK-3 beta pathways in CPB-related lung injury are unclear.关键词:...
创新点:首次探究了丝裂原活化蛋白激酶(mitogen-activated protein kinase,MAPK)、蛋白激酶B(protein kinase B,AKT)和核因子κB(nuclear factor kappa B,NF-κB)信号通路在温和气单胞菌诱导宿主细胞炎性应答中的作用及相关的分子机制,并分别从正反向进行了研究,围绕NF-κB、MAPK、磷酯酰肌醇-3-激酶(phosphatidylinosi...
Scutellaria baicalensis Attenuates Airway Remodeling via PI3K/Akt/NF-κB Pathway in Cigarette Smoke Mediated-COPD Rats Model Fei Xu#, Jinpei Lin#, Wenqiang Cui, Qing Kong, Qiuping Li, Lulu Li, Ying Wei*, and Jingcheng Dong* Evidence-Based Complementary and Alternative Medicine. Volume 2018, ...
并探究治疗作用是否与蛋白激酶(Protein kinase B,Akt1)/核因子κB(Nuclear factor kappa-B,NF-κB)/诱导型一氧化氮合酶(Inducible nitricoxide synthase,i NOS)通路有关.方法:1.选取体重24-28g雄性昆明小鼠50只,通过双侧颈总动脉重复夹闭和再灌注法复制VD小鼠模型.待小鼠麻醉清醒后进行评分检测,将成功造模的小鼠...
我们发现,NF-κB (nuclear factor kappa B, NF-κB)通路在IL-1β-in- induced inflammatory[13]中起重要作用。此外,我们还发现芦荟素通过降低p-p65/p65比值和逆转p65向核的易位来抑制NF-κ b通路。与我们的研究结果相似,既往研究显示芦荟素在治疗急性肺损伤[25]、破骨细胞形成[36]和血管炎症性疾病[32]中显...
GSK3β proteins are related to several signalling pathways including Wnt/β-catenin, nuclear factor kappa B (NF-κB), AKT, and nuclear factor erythroid 2 related factor 2 (Nrf2). Dysregulated GSK3β signalling is associated with the development of inflammatory syndromes, diabetic wounds, ...