The maximum concentrations used were 5 μM for ruxolitinib (a), 125 μM for CI-1040 (b), 16.7 μM for Ly294002 (c) and 5 μM for MK-2206 (d). Cell lines that showed no effect at the maximum inhibitor concentration were considered to be completely resistant to that inhibitor, and...
2024年ASCO大会报道的FLEX研究,根据70基因检测将HR+/HER2-早期乳腺癌患者分为:极低危组、低危组、高危(H1)、极高危(H2)。结果显示,H1患者接受多西他赛+环磷酰胺(TC)或环磷酰胺+蒽环序贯紫杉(AC-T) 的病理完全缓解(pCR)率(7.7% vs 7.0%)和3年无复发生存(RFS:97.1% vs 95.3%)均无差异,但H2患者接受AC-T...
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