作者的研究为Akt在癌症代谢调节中的一个关键作用提供了亟需的洞察力。 原文链接:https://www.nature.com/articles/s41586-022-04984-8 展示部分高价值问答与精品资源如下: 2022年医药加精品学习班直播档期 (支付学费可先领取全程视频,再参加一次腾讯会议直播,每月都轮回...
2 Tang, D., Kroemer, G. & Kang, R. Targeting cuproplasia and cuproptosis in cancer.Nat Rev Clin Oncol21, 370-388 (2024).https://doi.org:10.1038/s41571-024-00876-0 3 Tsvetkov, P.et al.Copper induces cell death ...
https://www.nature.com/articles/s41556-022-00949-1 p53和PI3K / Akt 01 根据威斯康星大学麦迪逊分校的一项最新研究，导致细胞癌变的两种最常见的基因变化，以前被认为是由不同的细胞信号分开调节的。迄今为止，研究人员一直专注于寻找阻断一种或另一种癌症治疗的药物。了解它们的协同效应可能会帮助我们找到更好的...
Received03 June 2022 Accepted06 September 2024 Published09 October 2024 Issue Date21 November 2024 DOIhttps://doi.org/10.1038/s41586-024-08031-6 Springer Nature Limited Share this article Anyone you share the following link with will be able to read this content:Get shareable link Provided by ...
doi:10.1038/s41586-024-08035-2 [7]Claudio Vernieri,et al.Comparison of antitumor efficacy of first-line palbociclib, ribociclib, or abemaciclib in patients with HR+/HER2- aBC: Results of the multicenter, real-world, Italian study PALMARES-2.J Clin Oncol 42, 2024 (suppl 16; abstr 1014)...
https://doi.org/10.1038/s41586-024-08031-6 制版人:十一 参考文献 1. Waks, A. G. & Winer, E. P. Breast cancer treatment: a review.JAMA321, 288–300 (2019). 2. Nik-Zainal, S. et al. Landscape of somatic mutations in 560 breast cancer whole-genome sequences.Nature534, 47–54 (...
DOIhttps://doi.org/10.1038/s41388-019-0724-7 Share this article Anyone you share the following link with will be able to read this content:Get shareable link Provided by the Springer Nature SharedIt content-sharing initiative Subjects Phenotypic screening Translesion synthesis Download...
术后4、12 周,每组分别取3只大鼠冈上肌腱-肱骨近端标本,进行大体观察。 1.3.2 Micro-CT观察 术后2、4、12周A、B组分别取3只大鼠冈上肌腱-肱骨近端标本,用 4%多聚甲醛固定,采用Micro-CT 进行三维重建分析骨隧道及周围骨组织的形成情况,检测以下指标:骨小梁分离度(bone trabecular separation,Tb.Sp)、骨...
reduced sphere diameters (Figure 2A,B). The PKH red signal from OCCs was concordant with the absence of proliferation in E4 + ECsjag1KD angiospheres (Figure 2C). Similarly, the number of invading endothelial tubes observed inside the sphere was significantly reduced (Supplementary Figure S4)....
S4d). SIRT6 expression elevated significantly after AKT inhibition, especially in HCT116 cells (Fig. 8b), and which showed a similar trend to PAR polymer (Fig. 8c). Overexpression of SIRT6 did not induce parthanatos directly (Fig. 8d) but enhanced AKT inhibition induced PAR polymer ...