Aside from PD-L1 expression, biomarkers of response to immune checkpoint inhibitors (ICIs) in non-small-cell lung cancer (NSCLC) are needed. In a previous retrospective analysis, we documented that fecal Akkermansia muciniphila (Akk) was associated with
Akkmensia. muciniphila是肠道中的一种细菌,在人肠道菌群中占比可达0.5-5%。目前研究已经证实,AKK在几种不健康情况下较低,例如肥胖、糖尿病、肠道炎症、肝脏疾病或慢性饮酒期间。 AKK减少会破坏肠屏障功能,导致血浆内毒素水平升高并最终引发低度炎症和代谢紊乱。 A. muciniphila及其衍生产物对宿主代谢的影响。 Akk...
2004年,荷兰瓦赫宁根大学微生物学实验室的研究者们 Muriel Derrien 等人从人类粪便中鉴定出了一种新的粘液降解菌:Akkermansia muciniphila(A. muciniphila,嗜粘蛋白-阿克曼氏菌,简称为Akk菌) [1] 。 Akk菌属于疣微菌门(Verrucomicrobia)唯一菌株,它以瓦赫宁根著名微生物生态学者 Antoon D. L. Akkermans(1941-...
Akkermansia muciniphila is a Gram-negative bacterium capable of degrading mucin and colonising the mucus layer of the gastrointestinal tracts of humans and animals. From:Trends in Food Science & Technology,2024 About this page Set alert Chapters and Articles ...
Secondary outcomes were gut barrier function (that is, plasma lipopolysaccharides) and gut microbiota composition. In this single-center study, we demonstrated that daily oral supplementation of 1010 A. muciniphila bacteria either live or pasteurized for three months was safe and well tolerated. ...
, includingAkkermansia. Administration of a commensal strain ofAkkermansiamuciniphilaimproved liver fibrosis and hyperammonemia with changing bacterial composition in the small intestine. This study proposed a new concept “small intestine-liver axis” in the pathophysiology of LC and oralA. muciniphila...
Akkermansia muciniphila, a member of the gut microbiome, has been shown to improve metabolism in mice. Here it is reported that its pasteurization further improves this effect, and that one of its membrane proteins by itself has a similar benefit. Obesit
muciniphila) holds great ability as a probiotic agent [12]. A. muciniphila is a Gram-negative, obligatory anaerobic, oval-shaped bacterium that breaks down mucus. It produces propionate and acetate as byproducts, which serve as food for other bacteria and the host [13]. This study aimed...
许多研究表明,Akkermansia.muciniphila(A.muciniphila)的定植可降低肠道屏障的通透性,有效地防止慢性低度炎性反应的发生,并且与机体糖代谢、脂代谢以及氨基酸代谢密切相关。糖尿病、肥胖等代谢性疾病患者体内的A.muciniphila丰度下降,补充后代谢状态改善。正确地认识A.muciniphila与代谢疾病的相关性及其发挥作用的机制,有...
Ever since Akkermansia muciniphila was discovered and characterized two decades ago, numerous studies have shown that the lack or decreased abundance of this commensal bacterium was linked with multiple diseases (such as obesity, diabetes, liver steatosi