参考文献: 1. Yu Z, Xu Z, Liang Y, Yin P, Shi Y, Yu J, et al.: Vitamin C Deficiency Causes Cell Type-Specific Epigenetic Reprogramming and Acute Tubular Necrosis in a Mouse Model. J Am Soc Nephrol, 33: 531-546, 2022 10.1681/ASN.2021070881 2. De...
There are various causes of acute kidney injury (AKI). Previously published textbooks by other authors classify these causes into three categories, partly for the purpose of differentiation (Sesso, Am J Kidney Dis 44:410–419, 2004). This chapter provides a general explanation of the causes of...
Kidney biopsy: Can be useful in identifying intrarenal causes of AKI and directing targeted therapy See Workup for more detail. Management In addition to treating the underlying etiology, maintenance of volume homeostasis and correction of biochemical abnormalities remain the primary goals of AKI treatme...
AKI: Specific causes and conditionsTO001ACUTE KIDNEY INJURY AFTER HEART- AND/OR LUNG TRANSPLANTATION: RETROSPECTIVE ANALYSIS OF INCIDENCE, RISK FACTORS AND... AKI: Specific causes and conditionsTO001ACUTE KIDNEY INJURY AFTER HEART- AND/OR LUNG TRANSPLANTATION: RETROSPECTIVE ANALYSIS OF INCIDENCE, RISK...
Although AKI is caused by numerous pathogenic factors, cell damage can induce inflammatory cascades that lead to cell death. In the initial stage of injury, some DAMPs (e.g., heat shock proteins and histones) are released to the outside of the cell, which causes tissue-resident cells such ...
Endotoxin uptake by S1 proximal tubular segment causes oxidative stress in the downstream S2 segment. J Am Soc Nephrol,2011,22:1505-1516. 15.Zhan M,Brooks C,Liu F,et al. Mitochondrial dynamics:regulatory mechanisms and emerging role in renal pathophysiology. Kidney Int,2013,83:568-581. ...
The second obstacle to establishing accurate information on causes of AKI and therefore on risk assessment is that we continue to have an incomplete understanding of the pathogenesis of AKI in many of the circumstances in which it is seen. Although there are many reasons for this, we and others...
- Causes can be prerenal, intrarenal, and postrenal. Prerenal AKI - Causes are factors that reduce circulation, causing a reduction in renal blood flow - EX: Severe dehydration, heart failure, hypotension, blood loss, hypoxia, sepsis/shock- Autoregulatory mechanisms attempt to preserve blood ...
B.U.O relieved w/48hrs of onset, can lead to tubular atrophy & irreversible kidney fibrosis Postrenal causes AKI 10%ACUTE KIDNEY Injury manifestations RIFLE CLASSIFICATION Risk Injury Failure Loss End stage renal disease AKI may progress through stages: Oliguric, Diuretic, Recovery ...
Introduction •Acutekidneyinjury(AKI),formerlyreferredtoasacuterenalfailure(ARF),isdefinedasanabruptreductioninkidneyfunctionmeasuredbyarapiddeclineinglomerularfiltrationrate.ThecausesofAKIarecategorizedasfollows •Prerenalazotemiaresultsfromeithervolumedepletion(hypovolemia),decreaseeffectivearterialpressure(shock),or...