Provided herein is a therapeutic composition that comprises an aryl hydrocarbon receptor (AhR) antagonist and an SRC inhibitor. In one embodiment, the therapeutic composition further comprises a pharmaceutical excipient. In one embodiment, the AhR antagonist is CH223191 and the SRC inhibitor is PP2 ...
The AhR‐SRC axis as a therapeutic vulnerability in BRAFi‐resistant melanomadoi:10.15252/emmm.202215677Paris, AnasTardif, NinaBaietti, Francesca MBerra, CyrilleLeclair, Hélose MLeucci, EleonoraGalibert, Marie‐DominiqueCorre, SébastienEMBO Molecular Medicine...
Furthermore, co-inhibition of AhR and Src reduced the growth of prostate cancer cells compared to individual treatments. Several studies have revealed that AhR and Src individually inhibit cellular proliferation. However, this study is the first to suggest simultaneous inhibition of AhR and Src to ...
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In pre-osteoclasts, tetrandrine enhanced the ubiquitination and degradation of Syk through the AhR/c-src/c-Cbl signaling pathway, downregulated the expression of phospho-Syk and phospho-PLCγ2, and inhibited the nuclear translocation of NFATc1, a master transcription factor for osteoclastogenesis. ...
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