PeptidesNeuropeptide YEnergy, PhysicsLaboratory mice肽类神经肽YMultiple hormones controlling energy homeostasis regulate the expression of neuropeptide Y (NPY) and agouti-related peptide (AgRP) in the arcuate nucleus of the hypothalamus. Nevertheless, inactivation of the genes encoding NPY and/or AgRP ...
PDK1-Foxo 1 in Agouti-Related Peptide Neurons Regulates Energy Homeostasis by Modulating Food Intake and Energy Expenditure.doi:10.1371/journal.pone.0018324Insulin and leptin intracellular signaling pathways converge and act synergistically on the hypothalamic phosphatidylinositol- 3-OH kinase/3-...
Jafarzadeh Shirazi MR, Tamadon A, Namavar MR. Coexpression of gonadotropin inhibitory hormone with Agouti-related peptide in the neurons of arcuate nucleus of ewe hypothalamus. Physiol Pharmacol. 2011; 15 :201–9.Jafarzadeh Shirazi MR, Tamadon A, Namavar MR. Coexpression of gonadotropin ...
Hypothalamic agouti-related peptide (AgRP)-expressing neurons are critically important for driving feeding and project axons to brain regions implicated in aggression and fear. Using circuit-mapping techniques in mice, we define a disynaptic network originating from a subset of AgRP neurons that project...
Here we demonstrate that induced selective ablation of AgRP-expressing neurons in adult mice results in acute reduction of feeding, demonstrating direct evidence for a critical role of these neurons in the regulation of energy homeostasis. 关键词: Feeding Peptides Neuropeptide Y Energy, Physics ...
Agouti-related peptide is upregulated in leptin deficient (ob/ob) mice and other models for obesity or diabetes (Ollmann et al., 1997; Shutter et al., 1997). Agouti-related peptide neurons project to many areas in the brain (Broberger et al., 1998; Blouet and Schwartz, 2010). In ...
As AgRP and the orexigenic peptide NPY are coexpressed in neurons of the arcuate nucleus, we generated AgRP and NPY double-knockout (Agrp(-/-);Npy(-/-)) mice to determine whether NPY or AgRP plays a compensatory role in Agrp(-/-) or NPY-deficient (Npy(-/-)) mice, respectively. ...
(p < 0.01) reduction was observed in food-restricted rats. Surprisingly, hypothalamic concentrations of alpha-MSH and its precursor peptide, pro-opiomelanocortin (POMC), did not differ significantly from controls in either model. In conclusion, we suggest that MC4-R activity may not be regulated ...
New tools for mapping and manipulating molecularly defined neural circuits have improved the understanding of how the central nervous system regulates appetite. Studies that focused on Agouti-related protein neurons, a starvation-sensitive hypothalamic population, have identified multiple circuit elements that...
Coexpression of Agrp and NPY in fasting-activated hypothalamic neurons. ProteinsIntercellular Signaling Peptides and ProteinsFastingIn Situ HybridizationHypothalamusAgouti-Related ProteinHahn TM, Breininger JF, Baskin DG, Schwartz MW... T.M. Hahn,J.F. Breininger,D.G. Baskin,... - 《Nature Neuros...