Agonist and Antagonist Drugs - The Differences Agonist drugs are given their name from the Latin word, “agnista”. This means “contender”. This enhances an action, rather than suppresses it, causing a reaction when the agonist drugs actually bind to the site of the receptor. It works duri...
It is now well established that a family of neuropeptides, the hypothalamic releasing and inhibiting or regulatory hormones, produced in neural cell bodies, regulate the secretory activity of the anterior pituitary (AP) gland. They are secreted at the level of the median eminence (ME) into the ...
Cholinergic agonist and antagonist drugs modulate the growth hormone response to growth hormone-releasing hormone in the rat: evidence for mediation by som... Recently, data have been presented showing that muscarinic cholinergic agonists or antagonists can modulate, in opposite ways, GH-releasing hormo...
Concurrent abuse of cocaine and heroin is a common problem. Methadone is effective for opioid dependence. The question arises as to whether combining agonist-like or antagonist-like medication for cocaine with methadone for opioid dependence might be eff
antagonist naloxone produced additive and synergistic antinociceptive effects in humans andcatsfor reasons that remain poorly defined (Table 23-5). The administration of opioid agonist-antagonist drugs or antagonists with full μ-agonists has not been evaluated in horses or cattle and remains ...
The method also comprises administering to the subject an antagonist to the drug or an agonist in an amount sufficient to at least partially block the pharmacologic effects of the drug or an agonist while there is a substantial amount of the drug or an agonist present in the system of the ...
Competitive antagonism occurs where an agonist drug or endogenous ligand is displaced from its receptors by an antagonist drug. Pharmacodynamics: how drugs act on the body The variable affinity and efficacy of different agonist drugs, and between different people, may be due to genetic variations in...
Terry Kenakin argues that clarification of such data — described in an extremely complex system — at a molecular level, will either obviate the need for terms such as inverse agonist or agonist/antagonist, or result in the rewriting of the classical receptor theory....
Respiratory depression is the opioid adverse effect most feared by an aesthesiologists. Specific κ-receptor agonists produce analgesia with little or no respiratory depression. There are a number of commercially available κ-receptor partial agonist drugs, the so-called agonist-antagonist or nalorphi...
Bullingham et al., “Clinical Pharamcokinetics of Narcotic Agonist-Antagonist Drugs”; Clinical Pharm (1983) 8: 332-343. Calimlim, et al. “Effect of Naloxone on the Analgesic Activity of Methadone in a 1:10 Oral Combination”; Clin Pharmacol and There (1974) vol. 15; No. 6 pp. 556...