Observations We report a case of agminated Spitz nevi arising in a nevus spilus and use exome sequencing to identify a clonal activating point mutation in HRAS ( GenBank 3265 ) (c.37G鈫扖) in the Spitz nev...
These lesions have arose on a pre-existent large congenital histologically confirmed nevus spilus extending along the face, neck, the left shoulder and the left chest wall. Histological examination of three excised nodules led to the diagnosis of Spitz nevus. Our patient may have a high risk ...
Downstream of AC, the phosphorylated transcription factor, cyclic AMP Responsive Element Binding Protein (pCREB), which is activated by protein kinase A, regulates the expression of several genes including the melanocyte master regulator MITF. The roles of AC and CREB in melanoma development and ...
Mosaic pathogenic HRAS variant in a patient with nevus spilus with agminated Spitz nevi and parametrial–uterine rhabdomyosarcomadoi:10.1111/bjd.16155K. NemethS. SzaboC.E. CottrellS.M. McNultyA. SeguraO. SokumbiM. BrowningD.H. Siegel