3a). These 2,236 features do not include the length of primary transcripts because typically it is not well defined within the GenBank sequence database. Among the 68 tissue–age pairs (17 tissues multiplied by 4 age comparisons to 4-month-old animals), 63 pairs had at least one of the...
Latz, E., and Duewell, P. (2018). NLRP3 inflammasome activation in inflammaging. Semin Immunol 40, 61–73. Article CAS PubMed Google Scholar Lautrup, S., Sinclair, D.A., Mattson, M.P., and Fang, E.F. (2019). NAD+ in brain aging and neurodegenerative disorders. Cell Metab 30,...
Touch screens are an unending aggravation.Study theiPhone commands, for example. Push up to get the display, pull down to select ‘Do not disturb’, but not too hard, because many other options appear. Push sideways, to change screens, move an icon around the screen, and, well, you know...
as well as cell renewal [24]; antioxidants, such asvitamin Cand B3, which prevent the formation of ROS induced particularly by UV radiation, thus reducingskin damageand preventing collagen impairment [22]; and moisturizers that improve water retention at the stratum corneum, often lost during the...
The scale of existing home and community care institutions is too small, the development of them lags behind, as well as many of them have difficulties of sustaining themselves. For example, more than 30,000 community service centers were built at the beginning of the 21st century, supported ...
At the event, I’ll be setting out my personal vision of “Transhumanism for all”: “Transhumanist benefits for all” – The tremendous benefits of new technology should become available to anyone who wishes to take advantage of them (rather than being restricted to the well off or the wel...
While many diseases of aging have been linked to the immunological system, immune metrics capable of identifying the most at-risk individuals are lacking. From the blood immunome of 1,001 individuals aged 8–96 years, we developed a deep-learning method based on patterns of systemic age-related...
Slipping is an obvious risk factor for falls, but there are many others as well: tripping over uneven surfaces like carpets; not paying close enough attention while walking; having poor balance because of muscleweakness, or wearing loose clothing that may catch underfoot while walking (this includ...
It is well known that NMJ nuclei are located beneath the endplate and produce essential components of the synaptic apparatus. In the present study, we identified a previously unreported NMJ accessory population that expressed marker genes related to synapse formation that were distinct from NMJ nuclei...
Neighborhood heterogeneity in health and well-being among the elderly in India—evidence from Study on global AGEing and adult health (SAGE). Health Place 47, 100–107 (2017). Article PubMed Google Scholar Belloni, G. & Cesari, M. Frailty and intrinsic capacity: two distinct but related ...