Taking together, aging is characterized by stable or even improved crystallized and social abilities, an early decline of sensory functioning and a somewhat later decline of fluid cognitive functions, the latter showing a huge interindividual variability. Most of the fluid functions are highly relevant...
The aging liver is characterized by lipid remodeling and loss of SRC in periportal mitochondria The spatial transcriptomic data suggested age-related metabolic alterations that depend on the location of cells with respect to central or portal regions. To gain more insight into the metabolic alterations...
Aging is characterized by multifaceted changes in the immune system which lead to a progressive reduction of the ability to mount effective antibody and cellular responses against infections and to vaccinations. This phenomenon, referred to as immunosenescence, is multifactorial: it affects both arms of...
The viability (survival ability) of a population is characterized in two actuarial functions: thesurvivorship curveand theage-specific death rate, or Gompertz function. The relation of such factors as aging characteristics,constitutionalvigour, physical factors, diet, and exposure to disease-causing orga...
Aging is characterized by the time-dependent deterioration of physiological integrity in almost all living organisms, and the hallmarks of aging include epigenetic alterations, mitochondrial dysfunction, proteostasis collapse, dysregulated metabolism, cellular senescence, genomic instability, telomere attrition, ...
Ovarian aging is a natural and physiological aging process characterized by loss of quantity and quality of oocyte or follicular pool. As it is generally accepted that women are born with a finite follicle pool that will go through constant decline witho
Older age is also characterized by the emergence of several complex health states commonly called geriatric syndromes. They are often the consequence of multiple underlying factors and include frailty, urinary incontinence, falls, delirium and pressure ulcers. ...
Such a scenario can be naturally associated with various problems in aged society, but what resulted in this change above? For one thing, the past 30 years was best characterized by the policy of Family Plan in China, which enabled a host of families to have only one kid and enabled the...
3g). In summary, liver aging is characterized by a gene-length-dependent, genome-wide loss of transcription elongation and increased RNAPII stalling. DNA damage causes transcription stalling in aging Subsequently, we assessed whether various potential parameters were correlated with the degree of GLPT ...
Aging is characterized by a number of physiological changes including loss of cell division, oxidative stress, DNA damage, nuclear changes, and increased expression of senescence-associated genes1,2,3,4,5. From the phenotypic point of view, aging might be defined as the progressive age-related ...