SenescenceFibrosisAgingKidney regenerationCell cyclingSASPSenolysisFibrosis is a hallmark of chronic kidney disease, and a primary risk factor for chronic kidney disease is age. Senescent cells accumulate in the kidney during natural aging and after injury. Understan...
The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing. Nat. Cell Biol. 12, 676–685 (2010). Article CAS PubMed PubMed Central Google Scholar Rajagopalan, S. HLA-G-mediated NK cell senescence promotes vascular remodeling: implications for ...
Acute kidney injuryMesenchymal stem cellsSecretome of MSCsCellular senescence is a phenomenon distinguished by the halting of cellular division, typically triggered by DNA injury or numerous stress-inducing factors. Cellular senescence is implicated in various pathological and physiological processes and is ...
Aging - Senescence, Mammals, Longevity: The lean body mass, consisting of the skeletal muscles and all other cellular tissues, decreases steadily after physical maturity until, in extreme old age, it may be reduced to two-thirds its value in young adults
Patients with advanced chronic kidney disease (CKD) have an impaired health status, reduced quality of life, and show an excess premature cardiovascular mortality that cannot be explained by traditional risk factors, such as dyslipidemia, hypertension, etc. The concept of vascular senescence and early...
Fig. 2. The feed-forward circuit between cellular senescence and compensatory immunosuppression. The pro-inflammatory phenotype of senescent cells evokes the inflammaging state involving a chronic low-grade inflammation. Inflammatory mediators provoke a counteracting immunosuppression which prevents the surveillan...
We found that various age-related contexts, such as prolonged quiescence and senescence, drive the accumulation of 5hmC with age. We provide evidence that this age-related transcriptionally restrictive function is conserved in mouse and human tissues. Our findings reveal that 5hmC regulates tissue-...
kidney failure, impaired vision and cardiovascular disease including atherosclerosis) but not others (such as cancer and neurodegeneration) during their infancy [18]. Similarly, Néstor–Guillermo progeria syndrome caused byBANF1mutations is associated with an aged appearance and skeletal abnormalities but ...
Senescent cells can remain in the body and contribute to multiple diseases as well as features of aging, ranging from heart disease to frailty, dementias, osteoporosis, diabetes, and kidney, liver, and lung diseases." "By targeting senescent cells with senolytics, we can delay, prevent, or ...
measured the whole transcriptome and incorporated temporal as well as physical health aspects into the analyses. In total, we used 18 different age-related pathological parameters and transcriptomic profiles of liver, kidney, spleen, lung and brain and created a database that can now be used for ...