Role of the Immune System in Aging and Longevity, Oxidative Stress and Skeletal Muscle Dysfunction with Aging, Glaucoma and Aging, Role of Insulin Signaling in the Interaction Between Alzheimer Disease and Diabetes Mellitus: A Missing Link to Therapeutic Potential, The Role of Cellular Senescence ...
et al. Sustained vision recovery by OSK gene therapy in a mouse model of glaucoma. Cell. Reprogram. 25, https://doi.org/10.1089/cell.2023.0074 (2023). Drake, S. S. et al. Cellular rejuvenation protects neurons from inflammation mediated cell death. Preprint at bioRxiv, https://doi.org/...
Here, we have attempted to identify and categorize the cellular and molecular hallmarks of aging. We propose nine candidate hallmarks that are generally considered to contribute to the aging process and together determine the aging phenotype (Figure 1). Given the complexity of the issue, we have ...
Age-related macular degeneration (AMD) and glaucoma are the most common retinal diseases with ND background and have an increasing prevalence. Irreversible loss of neurons, together with glial, microglial, extracellular, and vascular reactions are found both in the brain and retina and can show ...
These detrimental effects were potentially mediated by accelerated RGC senescence through Caveolin-1 upregulation and by the induction of mitochondrial dysfunction. In mouse models of high-tension glaucoma, Sirt6 level was decreased after IOP elevation. Genetic overexpression of Sirt6 globally or ...
Sperm contains high concentrations of spermidine, which prevents cellular senescence and allows long-term survival of the germ cell line. The homeostasis of spermidine is influenced by nutritional intake, intestinal microflora, endogenous biosynthesis, degradation and intercellular transport systems [64]. ...
& Xia, X. GSK872 and necrostatin-1 protect retinal ganglion cells against necroptosis through inhibition of RIP1/RIP3/MLKL pathway in glutamate-induced retinal excitotoxic model of glaucoma. J. Neuroinflammation 19, 262 (2022). Article CAS PubMed PubMed Central Google Scholar Liu, Y. et al...
Altered intestinal microbiota composition in later life is associated with inflammaging, declining tissue function, and increased susceptibility to age-associated chronic diseases, including neurodegenerative dementias. Here, we tested the hypothesis tha
Genetic ablation of Gpnmb-positive cells attenuated senescence in adipose tissue and improved systemic metabolic abnormalities in mice fed a high-fat diet, and reduced atherosclerotic burden in apolipoprotein E knockout mice on a high-fat diet. We then immunized mice against Gpnmb and found a ...
gozel B. Zhutdieva1, Christoph Brochhausen2, Aytan Musayeva1, Jenia Kouchek Zadeh1, Norbert Pfeiffer1, Ning Xia3, Huige Li 3, Juergen Wess4 & Adrian Gericke1 Muscarinic acetylcholine receptors have been implicated as potential neuroprotective targets for glaucoma....