CELLULAR SENESCENCE: A NOVEL CONTRIBUTOR TO BRAIN AGING AND NEURODEGENERATIVE DISEASEdoi:10.1093/geroni/igy023.810J K AndersenOxford University Press (OUP)Innovation in Aging
2022年8月18日，刘幼硕教授团队在Frontiers in aging neuroscience(IF=5.702) 在线发表题为“Accelerated aging-related transcriptome alterations in neurovascular unit cells in the brain of Alzheimer’s disease”的研究论文，该研究首次提出衰老通过调控神经-血管单元功能，影响阿尔兹海默病的发生和进展。研究通过对...
Villeda led the study on young blood, which was published in Nature. Dena Dubal, MD, Ph.D., UCSF professor and David A. Coulter Endowed Chair in Aging and Neurodegenerative Disease, led the study on klotho, which was published in Nature Aging. Tara Walker, Ph.D., professor of neuroscie...
Parkinson’s disease is a neurodegenerative disease that seriously endangers the health of middle-aged and old people and is characterized by the degeneration of nigrostriatal dopaminergic neurons as its main pathologic feature. Due to its numerous influencing factors, unclear pathogenic mechanisms, and c...
Aging is the major predictor for developing multiple neurodegenerative diseases, including Alzheimer's disease (AD) other dementias, and Parkinson's disease (PD). Senescent cells, which can drive aging phenotypes, accumulate at etiological sites of many age-related chronic diseases. These cells are ...
In these conditions, we can expect an epidemic progression of most chronic diseases, especially cardiovascular, neurodegenerative and metabolic disorders, the main causes of death in the world.Increasing life expectancy is concomitant with increased risk of aging-associated diseases, e.g., obesity, ...
郑州大学第一附属医院刘佩佩副研究员、康建胜教授、任凯迪主管药师,郑州大学辛永娟博士及汕头大学医学院黄冰教授合作在Aging Cell杂志上在线发表题为Neuronal cathepsin S increases neuroinflammation and causes cognitive decline via CX3...
The authors show that neuroprotective and neurotoxic astrocytes represent transitional cellular substates present during neuroinflammation and that targeting mTOR in astrocytes reduces neurotoxicity, suggesting a potential therapeutic strategy for neurodegenerative diseases. ...
with particular emphasis on aging and lifespan regulation across species and CNS function in the mammalian system. Lastly we will summarize the published literature highlighting a critical role of FoxO in age-associated metabolic and neurodegenerative diseases, in particular T2DM and AD, and provide ou...
Sleep–wake cycles are known to be disrupted in people with neurodegenerative disorders. These findings are now supported by data from animal models for some of these disorders, raising the question of whether the disrupted sleep/circadian regulation contributes to the loss of neural function. As ci...