YAP signalling promotes aggressive tumour development over heterotopia in the brainHere we describe the conditional zebrafish cancer toolbox, which allows for fine control of the expression of oncogenes or downregulation of tumor suppressors at the spatial and temporal level. Methods such as the Gal4...
Single-cell 'atlas' reveals origin of an aggressive brain tumor单细胞 "图谱 "揭示了一种侵略性脑瘤的起源 对小鼠的研究已经使百科全书充满了突破性的医学发现。但是当涉及到脑癌时,这种小啮齿动物长期以来一直表现出基本的局限性。 其中包括:人类小脑的表面积是小鼠的750倍,所有这些表面积都布满了更多类型的祖细...
cells from within,” says Huang, whose previous research demonstrating that brain tumor cells are mechanosensitive helped to inform the approach. “By combining our expertise in biochemistry at SickKids and engineering at U of T, we’ve developed a potential new way to treat aggressive brain ...
Pictured are MRI scans of eight patients with glioblastoma, an aggressive brain tumor. A new study led by Washington University School of Medicine in St. Louis has mapped out detailed molecular and genetic schematics of these tumors, opening the door to potential improved therapies. Credit: ALBERT...
Embryonal tumors are the most common brain tumors in infants less than 36 months. Histologically characterized as undifferentiated small, round cell tumors with divergent patterns of differentiation, these include medulloblastoma, the most common form of embryonal tumor, as well as supratentorial primitive...
Cadherin switching is also common during epithelial tumor progression, where it is thought to promote tumor invasion and metastasis. E-cadherin is the predominant cadherin expressed in epithelial tissues, but its expression is very limited in normal brain. We identified E-cadherin expression in a ...
An aggressive brain tumor (glioblastoma), illustrated based on magnetic resonance data. Credit: Karl-Heinz Nenning Glioblastoma is a highly aggressive brain cancer that predominantly affects people in their 50s, 60s and 70s. Even under the best available care, half of the patients die within one ...
The orthotopic tumors are passaged in the brain, without adaptation to culture. We co-infused [1,2- 13 C]acetate and [1,6- 13 C]glucose for 2 hours in tumor-bearing mice and then analyzed the resected tumor by 13 C-NMR. In addition, we infused [1,2- 13 C]acetate in patients ...
An image of BAP1 immunohistochemistry of a rhabdoid meningioma sample from a patient that carries a BAP1 mutation. The protein is completely lost in the tumor cells but is still fully maintained in normal blood vessel cells and in infiltrating fibroblasts and immune cells. Credit: Sandro Santagata...
Glioblastoma (GBM) is the most common intrinsic brain tumor in adults, accounting for 67% of primary brain tumors. Giant cell glioblastoma (GCG) is a rare variation of GBM, occurring in less than 5% of the cases. GCG has been demonstrated to affect younger patients and have a more indolent...