According to researchers, led by Michael Thun, MD, recently retired vice president emeritus of the American Cancer Society, women are smoking at rates similar to men, more so than in previous generations.Dr. Thun and his colleagues measured 50-year trends in mortality related to smoking across ...
The PSA(-/lo) prostate cancer cell population harbors self- renewing long-term tumor-propagating cells that resist castration. Cell Stem Cell 10, 556–569 (2012). 3. Shen, M. M. & Abate-Shen, C. Molecular genetics of prostate cancer: new prospects for old challenges. Genes Dev. 24, ...
However, the current study had adequate statistical power to evaluate individual and SNP combination effects in relation to prostate cancer. In particular, MDR has 80% statistical power to evaluate all possible two-, three-, and four-way gene-gene interactions with as low as 200 cases and 200...
Human xenograft prostate tumors, LAPC9 (bone metastasis; AR+ and PSA+), LAPC4 (lymph node metastasis; AR+ and PSA+), LNCaP (lymph node metastasis; AR+ and PSA+), DU145 (brain metastasis; AR- and PSA−), and PC3 (bone metastasis; AR- and PSA−) were maintained in NOD/SCID or...
Neuroendocrine prostate cancer NHA: Novel hormonal agent NED: Neuroendocrine transdifferentiation OS: Overall survival PCa: Prostate cancer PDX: Patient-derived xenografts PSA: Prostate specific antigen TME: Tumor microenvironment t-NEPC: Treatment-emergent neuroendocrine prostate carcinoma...
However, the current study had adequate statistical power to evaluate individual and SNP combination effects in relation to prostate cancer. In particular, MDR has 80% statistical power to evaluate all possible two-, three-, and four-way gene-gene interactions with as low as 200 cases and 200...
In the second cohort, they found a significant difference in response to common hormone therapy treatments, depending on the cancer's level of BCL2. The PSA level—a marker of prostate cancer—fell by more than 50% in only 12.5% of those with higher levels of BCL2, compared with 47.6% ...
In this cohort, every patient with a PSA level higher than 10 ng/mL had either a T2:ERG score greater than 7.6 or a PCA3 score greater than 19.1. We next sought to validate whether combining urinary T2:ERG and PCA3 measurement improves specificity of predicting aggressive prostate cancer via...
(the lowest level a PSA drops following treatment) greater than 0.5 ng/mL following radiation and androgen deprivation therapy seems to identify men prior to PSA failure who are at high-risk for death, and would thus require more aggressive treatment for their prostate cancer, according to t...
Cellular localization of Cx26, Cx32 and Cx43 in prostate Cancer cell lines Considering that, at the protein level, only connexins Cx26, Cx32, and Cx43 exhibited a correlation with the aggressiveness of PCa cell lines. Our objective was to explore the cellular localization of these connexins...