One percent to 5% of normal PBMs comprise NK cells; in most cases, leukemias arise from normal phenotypic counterparts. This case demonstrated that aggressive NK cell leukemia may occur in adults. In addition, the chromosomal abnormalities suggest that this is not a reactive process but a ...
A common (50% of fibroproliferative lesions of musculoaponeuroses of childhood), slowly infiltrative, non-tender, non-metastasising, but locally aggressive myofibroblastic neoplasm of younger (mean age 40) adults that is the most common tumour of mesentery. It arises in the stomach, GI tract,...
What is chronic leukemia? What is aggressive B-cell lymphoma? What is acute lymphoblastic leukemia? What kind of cancer is leukemia? What is chronic myeloid leukemia? What is the most common form of childhood leukemia? What leukemia is most common in adults?
Patients with chronic lymphocytic leukemia (CLL) are at a significantly increased risk of developing cutaneous squamous cell carcinoma (SCC), in part because of their impaired immunosurveillance. Here, we report the cases of 4 patients with CLL who had locally aggressive cutaneous SCC managed with ...
Combined interphase fluorescence in situ hybridization elucidates the genetic heterogeneity of T-cell acute lymphoblastic leukemia in adults. Haematologica 2010; 95: 79–86. 8 Bassan R, Masciulli A, Spinelli 0, Intermesoli T, Oldani E, Rossi G et al. New first line chemotherapy program with ...
The most common entities of PML are T-lymphoblastic leukemia/lymphoma (T-ALL/LBL), primary mediastinal (thymic) large B-cell lymphoma (PMBL), primary mediastinal “nonthymic” diffuse large B-cell lymphoma (DLBCL) and mediastinal nodular sclerosis classic Hodgkin lymphoma (NSCHL). Rarer entities...
Inversion of chromosome 16 (inv(16)) generates a fusion gene CBFB-MYH11, which is a driver mutation for acute myeloid leukemia (AML). Gene expression profiling suggests that Gata2, a hematopoietic transcription factor, is a top upregulated gene in preleukemic Cbfb-MYH11 knockin mice and is...
Lenalidomide can be safely combined with R-CHOP (R2CHOP) in the initial chemotherapy for aggressive B-cell lymphomas: phase I study. G S Nowakowski,B... GS Nowakowski,B Laplant,TM Habermann,... - 《Leukemia》 被引量: 0发表: 2011年 Combination of Lenalidomide with R-CHOP (R2CHOP) Is...
Aggressive therapy-resistant and refractory acute myeloid leukemia (AML) has an extremely poor outcome. By analyzing a large number of genetically complex and diverse, primary high-risk poor-outcome human AML samples, we identified specific pathways of therapeutic vulnerability. Through drug screens foll...
Professor Kamil Kranc, at The Institute of Cancer Research, London, said, "Therapy for acute myeloid leukemia has barely changed in several decades. There is a huge need to discover better treatments for this aggressive disease. We've shown for the first time that targeting the pathways that ...