Glioblastoma originates in glial cells that support and protect the neurons. At some point these cells begin to multiply without control. The life expectancy of patients with this cancer is between 11 and 27 months. One of the problems in treating cancer is developing resistance to chemotherapy. ...
Mechanical nanosurgery, a new approach developed by scientists at The Hospital for Sick Children and the University of Toronto, uses magnetic carbon nanotubes to target and destroy chemoresistant glioblastoma cells. The technique has potential applications in treating other cancer types by changing the ...
There is an association between the low MGMT expression, due to gene silencing by MGMT promoter methylation, and the response to TMZ treatment in glioblastomas (129). The value of MGMT status as a predictor of TMZ response in aggressive pituitary tumours is less clear. Promotor methylation of ...
Beyond TNBC, FOXM1 is implicated in other solid cancers, such as brain (glioblastoma), lung, and pancreatic cancers, and is considered an Achilles’ heel of aggressive cancers. Despite its potential as a therapeutic target, there are currently no FDA-approved FOXM1 inhibitors, and none have ...