Interphase TACC3 interacts with the nucleosome remodeling and deacetylase (NuRD) complex (HDAC2 and MBD2) in nucleus to inhibit the expression of key tumor suppressors (e.g., p21, p16 and APAF1) driving G1/S progression, and its inhibition blocks these interactions and causes p53-independent ...
Data S1. PCA of PARCB time course as a 3D rotatable object, related to Figure 1E Data S2. Projection of RNA-seq as a 3D rotatable object, related to Figure 5A Data S3. Projection of ATAC-seq as a 3D rotatable object, related to Figure 5A Table S1. Supplemental information of bioinf...
45 Familial prostate cancer has a more aggressive course than sporadic prostate cancer after treatment for localized disease, mainly due to a higher rate of distant metastasesPurpose: We had already established that familial prostate cancer, defined as prostate cancer diagnosed in a father or brother...
(Figure 1andFigure 2). Then, a second biopsy was taken from the same primary tumor at month two, and the patient started chemotherapy treatment. This second sample had different driving alterations and only shared theIGF1Ramplification with the previous sample. At the ninth month, a mastectomy...
Since we have shown that KIFC1 RNA levels are notably higher in AR-low TNBCs than in AR-high TNBCs, next, we investigated whether KIFC1 could be driving the poorer prognosis observed in QNBCs relative to AR-positive TNBCs. Hence, we analyzed the influence of KIFC1 on survival outcomes....
The role of aberrant NIK activity in driving DLBCL lymphomagenesis has been verified in a mouse model with constitutive transgenic NIK and BCL6 expression in GC and post-GC B cells [67]. The observation that the canonical or alternative NF-κB pathways can be found activated by genetic ...