PKM2 is involved in the aging process but the mechanism remains elusive. Here, the authors show that PKM2 forms aggregates during aging and identify two small molecules which can dissolve the PKM2 aggregates and delay aging. Juntao Bie
Because of the many time scales involved in amyloid aggregation, both coarse-grained and atomistic models have been used to simulate this process. Here I focus on explicit-solvent all-atom MD simulations, as in principle, they capture the full dynamics of the aggregation process at atomic ...
Protein phase separation and aggregation are crucial in driving the assembly of various membraneless compartments and functional biomolecular condensations involved in a wide range of biological processes. Under diseased conditions, imbalance of protein homeostasis may lead to protein misfolding and pathologic...
The algorithm is shown to identify a series of protein fragments involved in the aggregation of disease-related proteins and to predict the effect of genetic mutations on their deposition propensities. It also provides new insights into the differential aggregation properties displayed by globular ...
NEW DRUG PREPARATION FOR INHIBITING AGGREGATION OF PROTEINS INVOLVED IN DISEASES RELATED TO AGGREGATION OF PROTEINS, AND NEURODEGENERATIVE DISEASESFIELD: medicine, pharmaceutics.;SUBSTANCE: invention refers to a compound presented by formula (E) ; --- means an optional double bond; R1, R2, R3, R4...
Olfactory dysfunction is an early pre-motor symptom of Parkinson’s disease (PD) but the neural mechanisms underlying this dysfunction remain largely unknown. Aggregation of α-synuclein is observed in the olfactory bulb (OB) during the early stages of P
If multiple users are processing related data concurrently, a complicated locking mechanism may be involved. For example, if the approver is approving the purchase request, and the purchase submitter is modifying the purchase item, it may cause the reviewed data to be out of date or cause the ...
( 2007 ) Genetic and pharmacologic evidence that Rac1 GTPase is involved in regulation of platelet secretion and aggregation . J Thromb Haemost 5 : 1747 – 1755 .Akbar H, Kim J, Funk K, Cancelas JA, Shang X, Chen L, Johnson JF, Williams DA, Zheng Y (2007) Genetic and pharmacologic ...
The extracted cells of another mutant failed to form aggregates even in the presence of the aggregation factor, indicating that some other component(s), different from the aggregation factor, is involved in the flocculation. Sodium dodecyl sulfate polyacrylamide gel electrophoresis of the envelope ...
N. Ishihara et al., “Inhibition of apoptosis-inducing factor translocation is involved in protective effects of hepatocyte growth factor against excitotoxic cell death in cultured hippocampal neurons”, Journal of Neurochemistry, vol. 95, No. 5, pp. 1277-1286, 2005. Extended European Search Rep...