α-Synuclein (αSyn) aggregation is involved in the pathogenesis of Parkinson disease (PD). Recently, substitution of histidine 50 in αSyn with a glutamine, H50Q, was identified as a new familial PD mutant. Here, nuclear magnetic resonance (NMR) studies revealed that the H50Q substitution ...
PKM2 is involved in the aging process but the mechanism remains elusive. Here, the authors show that PKM2 forms aggregates during aging and identify two small molecules which can dissolve the PKM2 aggregates and delay aging. Juntao Bie
Protein phase separation and aggregation are crucial in driving the assembly of various membraneless compartments and functional biomolecular condensations involved in a wide range of biological processes. Under diseased conditions, imbalance of protein homeostasis may lead to protein misfolding and pathologic...
NEW DRUG PREPARATION FOR INHIBITING AGGREGATION OF PROTEINS INVOLVED IN DISEASES RELATED TO AGGREGATION OF PROTEINS, AND NEURODEGENERATIVE DISEASESFIELD: medicine, pharmaceutics.;SUBSTANCE: invention refers to a compound presented by formula (E) ; --- means an optional double bond; R1, R2, R3, R4...
In this article, we will learn about the need for log aggregation, the steps involved in log aggregation, and the types of logs you should collect. We’ll also consider the features you need to look for when choosing a log aggregation and management platform. ...
According to still a further aspect of the invention, there is provided a method for the treatment of any disorder where platelet aggregation is involved, whereby an effective amount of a compound according to the formula (I) is administered to a patient suffering from said disorder. Pharmaceuti...
N. Ishihara et al., “Inhibition of apoptosis-inducing factor translocation is involved in protective effects of hepatocyte growth factor against excitotoxic cell death in cultured hippocampal neurons”, Journal of Neurochemistry, vol. 95, No. 5, pp. 1277-1286, 2005. Extended European Search Rep...
Olfactory dysfunction is an early pre-motor symptom of Parkinson’s disease (PD) but the neural mechanisms underlying this dysfunction remain largely unknown. Aggregation of α-synuclein is observed in the olfactory bulb (OB) during the early stages of P
The extracted cells of another mutant failed to form aggregates even in the presence of the aggregation factor, indicating that some other component(s), different from the aggregation factor, is involved in the flocculation. Sodium dodecyl sulfate polyacrylamide gel electrophoresis of the envelope ...
Because so many different technologies are involved in broadband access aggregation, it is important that the service provider understand their network both in terms of the hardware that makes up the installation, which determines what type of sessions need to be established, but also in terms of ...