Are non-steroidal anti-inflammatory drugs harmful to the stomach when taken parenterally, for example by intravenous or intramuscular routes? Is it safe to give a patient with a past history of bleeding peptic ulcer aspirin in an antiplatelet dose of 75-3 Dig...
It should be noted that regulatory members of the Bcl-2 family can neutralize prosurvival and activate proapoptotic proteins, and effectors which also participate in the permeabilization of the outer mitochondria membrane [22, 23]. Altogether, BH3-mimetics along with MDM2 antagonists promote ...
andtheacidandpepsin. HelicobacterpyloriInfection Causes80%ofpepticulcers Survivestheacidenvironmentbyattachingtothesugarmoleculesthatlinethestomachwall Usesthemucus layerasprotection H.pylori Producelargeamountsofurease Urease H20 3NH3+CO2 Urea H.pylori Secretproteinsandtoxinsthatinteractwiththestomach’s...
The term “rescue agent” means any molecule that is effective to compete (directly or indirectly) with an active botulinum toxin, and thereby neutralizes the intoxicating effects of the active botulinum toxin. For example, a rescue agent may comprise an iBoNT that can compete with the active ...
The "fluorescein ester compound" refers to a compound resulting from a reaction of an acid with fluorescein at the hydroxyl group(s) to form an ester linkage. Fluorescein and the acid may be modified. The "13 C- or 14 C-labeled" means that at least one carbon atom in the fluorescein...
Interestingly, in normal cells that effect did not take place. Betulinic acid, doxorubicin, VP16, taxol and actinomycin D induced apoptosis in the SHEP cell line [114]. In some cases, betulinic acid can work as a cell sensitizer for other anticancer agents, such as doxorubicin, in a wide ...
Gram-positive bacteria have a thick layer of peptidoglycan formed by linear chains alternating residues of N-acetylglucosamine (NAG) and N-acetylmuramic acid (NAM) linked together by a sequence of 3 to 5 amino acids that cross-link each other, forming a cohesive mesh. Additionally, ...