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Microtubule targeting agents (MTA) are anti-cancer molecules that bind tubulin and interfere with the microtubule functions, eventually leading to cell death. In the present study, we used an in vitro microtubule polymerization assay to screen several venom families for the presence of anti-microtubul...
(broad-spectrum antibacterial, anti-biofilm, and anti-quorum sensing activities) of melittin, a membrane-active peptide present in bee venom. The minimum inhibitory concentration and minimum bactericidal concentration of the melittin were determined using the microdilution method and agar plate counting. ...
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The impor- tance of Kv1.2 channels in controlling neuronal excitability has been demonstrated by the observation that Kv1.x (Kv1.1 and Kv1.2) channel-inhibiting venom toxins induce seizures in rodents[19]. To evaluate the effect of DC0310050 on the neu- ronal potassium channels KCNQ2 and Kv...
venom were subjected to a pharmacological screening process and were found to possess analgesic and anti-inflammatory activities[98]. Many of the flavonoids isolated from AfricanDorsteniashow moderate to good anti-oxidant activities [Croft, unpublished results]. The cytotoxic properties of 6,8-di...
With venom for blood she has filled their bodies. Roaring dragons she has clothed with terror, Has crowned them with haloes, making them like gods, So that he who beholds them is overcome by terror, Their bodies rear up and none can withstand their attack. ...