Individualization of drug therapy requires that the right drug be administered at the correct dose to patients who are likely to achieve the highest benefit and lowest risk. Female sex and age comprise two important risk factors for altered drug exposure and response. This review summarizes the cur...
PowerLOW was tested using the standing long jump test. Out of a standing frontal posture the children had to jump as far as they could. The participants had to land with both feet together. They were allowed to swing their arms prior to and during the jump, but after landing the hands ...
Bone density testing in older women and its association with patient age. J Am Geriatr. 2006;54(3):485-489.Neuner JM, Binkley N, Sparapani RA, et al. Bone density testing in older women and its association with patient age. J Am Geriatr Soc. 2006; 54:485-489. [PubMed: 16551317]...
The density of the bone (bone mineral density) normally begins to decrease in women during the fourth decade of life. However, that normal decline in bone density is accelerated during the menopausal transition. Consequently, both age and the hormonal changes due to the menopause transition act ...
As you get older, your provider will start to screen you for osteoporosis with bone density tests. In general, the U.S. Preventive Services Task Force recommends that women and individuals assigned female at birth should be screened starting at age 65 because they’re at higher risk. ...
Elderly man sitting in a bed next to a wheelchair. Many people are familiar withosteopeniaandosteoporosis,which are conditions characterized by moderate and severe bone density loss, respectively, that can occur as you age. However, sarcopenia, the age-related decline in muscle mass and function...
50 × 41 × 6 cm; density = 55 kg/m2), (3) eyes closed on a compliant surface (ECC), (4) eyes closed on a compliant surface while wearing noise-cancelling headphones for sound suppression (ECSS). Participants wore a loose harness during the procedure to protect against fa...
Epigenetic change is a hallmark of ageing but its link to ageing mechanisms in humans remains poorly understood. While DNA methylation at many CpG sites closely tracks chronological age, DNA methylation changes relevant to biological age are expected to
Prior research establishing that bone interacts in coordination with the bone marrow microenvironment (BMME) to regulate hematopoietic homeostasis was largely based on analyses of individual bone-associated cell populations. Recent advances in intravital
TGFβ1 induces age-related bone loss by promoting degradation of TNF receptor-associated factor 3 (TRAF3), levels of which decrease in murine and human bone during aging. We report that a subset of neutrophils (TGFβ1+CCR5+) is the major source of TGFβ1