Under a Creative Commons license open accessAbstract Individualization of drug therapy requires that the right drug be administered at the correct dose to patients who are likely to achieve the highest benefit and lowest risk. Female sex and age comprise two important risk factors for altered drug ...
2b). We quantified these differences using ImageJ to determine the percentage of inter-tissue white space, as a surrogate for adiposity of the submucosal regions. There was a significant correlation between white space and transverse colon normalized ADIPOQ levels in the submucosa, based on the ...
Therefore the question arises how many anti-HCV-positive blood donors were missed by the EIA-1, how many were false positive, how false-positive donors should be dealt with and how the results of the EIA-2 correlate with demographic data and surrogate testing for serum alanine aminotransferase ...
Predictions were made using a LOCO approach, where each cohort was excluded in training and the resulting model was used for testing (see Methods). Models were trained on age, and if an individual was predicted to be under 20, their prediction was re-estimated considering models trained on ...
Here, the authors developed a DNA methylation clock surrogate for longitudinal health and biomarker measurements to more directly predict an individual’s ageing rate instead of relying on cross-sectional measures of relative biological age. Article CAS PubMed PubMed Central Google Scholar Belsky, D...
In fact, one dramatic surrogate case from South Africa involved the transfer of embryos from a 25 year-old woman who had lost her uterus to her 48 year-old mother who was menopausal but still had a uterus. The mother “grandmother” got pregnant in the first cycle with triplets...
Several studies have suggested that AMH could be used as a surrogate marker for the diagnosis of PCOS [10,11,12]. However, the majority of these studies have some shortcomings, mainly due to not being age-specific, as marked changes occur in AMH across the reproductive lifespan in the norm...
UK: pay your international surrogate, lose the rights to your child? Abortion facts and figures View more Abortion In the Sixth Month of Pregnancy Or Later: Late-term Abortion or Termination of Pregnancy Abortion: Methods And Post-Procedure Care Obama Cheers Planned Parenthood, Including Ab...
The inconsistency is most likely due to that radiographic joint space is only a surrogate measure of articular cartil- age thickness, such that a small change in knee cartilage volume may not be captured in radiographs. Further- more, radiographic joint space width can ...
Therefore, the age-associated changes in sex hormones may be one reason for the conflicting results of sex and survival outcomes. In the current study, we hypothesized that the effect of sex on oncologic outcomes is modified by age, which was used as a surrogate for hormone status. To test...