A systemic decline in autophagic activity with age can subsequently impair homeostasis in skin tissues(Fig.3), leading to age-related diseases. In contrast to other tissues, aged adipocytes upregulate autophagy based on a decline in Rubicon expression and subsequently exacerbate the excessive autophagic...
A systemic decline in autophagic activity with age can subsequently impair homeostasis in skin tissues(Fig.3), leading to age-related diseases. In contrast to other tissues, aged adipocytes upregulate autophagy based on a decline in Rubicon expression and subsequently exacerbate the excessive autophagic...
Furthermore, PAPLAL normalized the expression of extracellular matrix-related genes in the skin of Sod1 / mice. Other materials, such as vitamin C derivative, collagen peptides, and resveratrol, also attenuate age-related skin pathologies via the normalization of reactive oxygen species metabolism ...
But age-related muscle loss isn’t just a cosmetic issue. So much of the loss of function and vitality that commonly accompanies aging actually begins with this gradual loss of muscle tissue starting in mid-life. As we lose muscle, we lose strength and stamina and this means we can’t do...
Aging is the process that progressively transforms young adult organisms into aged ones with changes across multiple physiological systems [11,162,163,164,165], leading to the emergence of a large number of age-sensitive phenotypes (ASPs), such as loss of bone density, skin thinning, atherosclero...
The hypodermis, with its fat stores, loses structure due to the reduction and redistribution of fat, which in turn contributes to the thinning and sagging of skin. Figure 4.17. Aging Generally, skin, especially on the face and hands, starts to display the first noticeable signs of aging, as...
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Age-related macular degeneration Diagnosis Genetics Mechanism Target treatment Introduction The macula is a circular area of diameter 5.5 mm with a center located 17°, or 4.0–5.0 mm, temporal, and 0.53–0.8 mm inferior to the center of the optic disc. The fovea centralis is a small, central...
Adjuvant long-term corticosteroid treatment is associated with increased risk for cataracts, osteoporosis, nerve damage, skin thinning, infection, and impaired wound healing. Adjuvant tamoxifen chemotherapy is also associated with cataracts, and radiotherapy is associated with dementia, memory loss, carotid...