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Our genetic results from GM-BAG substantiate that many diseases, conditions, and clinical phenotypes share genetic underpinnings with brain age, perhaps driven by macrostructural changes in GM (e.g., brain atrophy). The locus with the most significant signal (the top lead SNP rs534114641 at 17...
The participants were part of a consecutive cohort that initially included 1196 infants born with various birth risks in a single hospital in Helsinki between 1971 and 197416. A total of 202 children died or had severe disabilities, e.g. cerebral palsy, blindness or Down syndrome, and were ex...
There was a significant difference in age, sex, CC, the prevalence of cerebral infarction, and COPD prevalence in the two groups (P < 0.05). Serum FT3 values were significantly lower in non-survival sarcopenic patients compared to survival sarcopenic patients (3.7 ± 0.5 vs. 3.9...
Cerebral microbleeds are small perivascular hemorrages (2–10 mm) that can be detected histologically at autopsy or in vivo using iron-sensitive MRI sequences.44 Microbleeds, which are observed in 10% to 20% of the elderly often in association with other SVD pathologies, are an independent ...
Previous studies have shown that menopausal hormone therapy in postmenopausal women results in a higher prevalence of age-related macular degeneration. This study aimed to evaluate the effects of menopause and patient factors on the development of age-related macular degeneration in Korean women. Data ...
The aging process affects the structure and function of the nervous system and encompasses both gross and microscopic structural alterations, including cerebral atrophy, lipofuscin accumulation, and the presence of neurotoxic proteins like amyloid-beta and neurofibrillary tangles. Biochemical and metabolic cha...