000 sites in the DNA. Then computer programs are used to extract an age from some small subset of a few hundred sites. Once you have done the lab work, the difficult and expensive part is over. Calculating several different methylation ages is as simple as running the appropriate...
In two rat studies, cognitive flexibility was assessed using reversal learning paradigms [79,80]. In the reversal learning paradigm, rats were trained on simple (e.g., visual cue) and more complex discriminations (e.g., visual + scent cue) between rewarded and non-rewarded bowls. After...
First, the predictive value of variables age and sex to predict the clinical variable was investigated by constructing simple linear regression models with age and sex as independent variables (Table 1 in the Supplementary Information, Fig. 1). Relatively good performance metrics were achieved with ...
Simple linear regression models were fitted with GD, GHT, and PE as exposures, and the 3 different measures of age acceleration (EAA, IAA, and sex-adjusted IAA) were independently tested as responses. To assess the impact of each covariate on the model, we performed a forward stepwise ...
Thus, the DLR may be small for some patients even though the odds ratio for the negative risk marker obtained from the logistic regression analyses was large in the overall cohort. We calculated the MI and death event rate per 1000 person-years among patients with a CAC score of 0 and no...
The MCA convergence model enabled us to estimate the values of the reference category of the dependent variable which was not possible in the Cox proportional hazard model or simple linear regression analyses. The geospatial map was constructed to demonstrate the change in predicted mean age at ...
In communicating chronic risks, there is increasing use of a metaphor that can be termed ‘effective-age’: the age of a ‘healthy’ person who has the same risk profile as the individual in question. Popular measures include ‘real-age’, ‘heart-age’,
NIH Autism Regression Study Attempts to Ferret Out Answers By Katie WrightHere we go again, the NIH takes one step forward and then, immediately, one step backwards. The majority of researchers serving on the NIH Regressive Autism Workshop Panel were remarkably unacquainted with regressive autism...
Given the robust and effectively one-dimensional character of changes during aging, a sufficiently large dataset could be used to produce a universal transcriptomic biological age model, such as, in its simplest form, a regression of the gene expression levels on the chronological age, suitable for...
Standardized regression coefficients of age-at-menopause, and hormone-therapy-use with neocortical β-amyloid interactions in regional tau-SUVr adjusting for years of education eTable 3. Standardized regression coefficients of sex, age-at-menopause, and hormone-therapy-use neocortical β-amyloid ...