Table 1 summarizes the recommendations for considering age and sex in animal experiments. 2.3. Phase 1 and 2 clinical trials in humans In phase I trials drugs and biologics are tested in a small group of people for the first time to evaluate safety, determine a dosing range using ...
The age range of patients with NICE was 23–96 years. Based on the age distribution of patients included in the study, they were divided into four groups with a 10-year age interval, centered at 55, 65, and 75 years. The age ranges for each group were as follows: Group1 (G1) ...
AGE AND AGEING's scope encompasses a broad range of topics, including research on the aging process itself, as well as the clinical, epidemiological, and psychological facets of later life. This multidisciplinary approach makes it a valuable resource for researchers, clinicians, and profe...
- 《Journal of the American Geriatrics Society》 被引量: 131发表: 2000年 Growth Hormone Dynamics in Healthy Adults Are Related to Age and Sex and Strongly Dependent on Body Mass Index. Background: Studies on 24-hour growth hormone (GH) secretion are rare. The influences of sex, age, and...
The problems presented include the fact that different organs age at different rates; biological age depends on the parameters studied; ‘regression dilution bias’ may produce misleading results; the validity of the measurement has to be established; the age range for measures has ...
for vaccine and therapeutic development. In contrast, we found that none of our older or sex organ intact ferrets developed significant weight loss after SARS-CoV-2 infection, but temperature was significantly different between age-matched males and females. Given that the normal temperature range fo...
The mass range (m/z) was 70–1,050 for positive ion mode and 80–1,200 for negative ion mode93. The raw files of untargeted metabolomics were searched by using TraceFinder (Thermo Fisher Scientific) based on a homemade metabolite database. The mass tolerance of the precursor ions was 10...
BMC Geriatrics (2022) 22:821 Page 11 of 12 Conclusion This study provides descriptive data for the SPPB based on a large, population-based data set that includes a wide range in age and physical function. The results add to a better understanding of the diversity in health and func- tion...
with stable chairs that can be adjusted for a wide range of heights, child-sized desks, or chinrests that can restrain the head. It is recommended to invite children of each age group to evaluate all the experimental protocols at the design stage....
(Medical Information Mart for Intensive Care)32. The median age of this cohort was 71 years with an interquartile range of 61–80 and 2097 (8.5%) patients were male (Supplementary Fig.1d, h). Baseline characteristics of this cohort are shown in Supplementary Table11. In the multivariate ...