Effect of Age, Sex and Life Style on CHD Risk Factors: Influence of Obestiy and Body Fat DistributionThe degree of success or failure experienced by an organism in its effort to respond adaptively to an environmental challenge is estimated by different health indicators like fertility, mortality ...
We selected 51 phenotypes, including blood test parameters, anthropometric measurements, blood pressure and lifestyle factors (Supplementary Table 1 and Extended Data Figs. 1–3). Of these, 36 phenotypes (71%) exhibited linear sex differences over the whole age range (Supplementary Tables 2 and 3...
Several candidate accounts of age-related trajectories in ASC have been put forward [15]. On the one hand, neural and cognitive differences in ASC may be maintained across the lifespan and follow the same age-related decline as in typical individuals (parallel development hypothesis). On the ot...
Formerly very abundant, the global population of Egyptian vultures has experienced a severe decline throughout its range49. The Spanish population comprises ca. 80% of the European population and in some regions has seen a concerning decline in the last two decades31. Egyptian vultures are ...
In the age- and sex-adjusted analysis, for the optimal FBG range (4.44–5.2 mmol/l), the HR for all-cause mortality was 1.66, 1.21, 1.02, 1 (reference) and 1.12 for BMI <20, 20–22.4, 22.5–24.9, 25–27.4 and ≥27.5 kg/m2, respectively. In the high prediabetes range (FBG 6.1...
New horizons in the pathogenesis, diagnosis and management of sarcopenia Sarcopenia is the age-related loss of skeletal muscle mass and function. It is now recognised as a major clinical problem for older people and research in ... SA Aihie,SM Robinson,HP Patel,... - 《Age & Ageing》 被...
(Clapés et al.,2018; Principi et al.,2019; Rodriguez et al.,2017; Rosales and Fernández-Ardèvol,2019) and the United Kingdom (n = 4) (Abdurrahim et al.,2018; Georgopoulos et al.,2020a,2020b; Todd et al.,2019). The publication dates range from 2005 to 2021, and there ...
Moving forward, we aim to apply the HistoAge framework to a range of pathologies and disease populations, with the goal of gaining a deeper understanding of the connection between brain aging and neurodegeneration. By exploring the neuropathologic basis of various disorders and their clinicopathologic...
(Supplementary Fig. 5), and was robust to the entire range of significance thresholds (see Methods). This is consistent with a scenario where many methylation sites associate with chronolo- gical age, but only those with regulatory potential lead to altered transcript expression with chronological...
It was not possible to investigate possible associations between adherence to the interventions and life- style factors at baseline (i.e., physical activity and dietary habits), because data were not collected. Another limitation is the broad age range among the included children, which complicates...