As such sleep may also be a consequence of other attributes, such as pubertal timing, which have causal effects on some non-communicable diseases. Notably, puberty affecting sleep duration falls within the emerging paradigm of evolutionary public health, i.e., considering health within the well-...
This theory is supported by data from non-human primates under caloric restriction, that—despite showing significant life-span extension—suffered from an accelerated loss of gray brain matter, albeit without affecting cognitive performance54. Decoding the pathways implicated in accelerated aging and pro...
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As important music discovery sites, these platforms not only attract musicians but also advertisers looking to hire musicians for their social media campaigns, and record companies looking to promote their music and license it to these platforms. But the most followed musicians are backed by either ...
Age-related macular degeneration (AMD) is a leading cause of blindness that affects the central region of the retinal pigmented epithelium (RPE), choroid, and neural retina. Initially characterized by an accumulation of sub-RPE deposits, AMD leads to pro
We also determined whether repetitive TPE may regulate the complement system including C3 and C1q, which play a key role in immune responses and also participate in non-immune crosstalks of cell–cell signaling pathways [30,31,32]. When we examined 15 commercial human serum samples across young...
Ivermectin is a dirty word in the media. It doesn’t work. It’s a deadly horse dewormer. Prescribe or promote it and you’ll be called a right-wing quack, be banned from social media, or lose your license to practice medicine. And yet, entire countries wiped out the virus with it,...
Under a Creative Commons license open accessHighlights Summary Gene expression profiles of more than 10,000 individual microglial cells isolated from cortex and hippocampus of male and female AppNL-G-F mice over time demonstrate that progressive amyloid-β accumulation accelerates two main activated micr...
(iii) uPAR-positive cells with senescence signatures consist of both immune and non-immune populations, the latter consisting of a range of cell types that are organ dependent; (iv) uPAR CAR T cells can be effective at eliminating uPAR-positive senescent cells; (v) their effect is not ...
Bayesian kernel machine regression (BKMR)45 was conducted as a semi-parametric machine learning method to investigate non-linear dose–response associations, interactions among PFAS, and overall cumulative effects of the PFAS mixture. In this study, the BKMR models were applied as Yi = h (PFA...