Risk factors for MDD associated with lifetime smoking, controlling for the effect of age.Qiang HeLei YangShenxun ShiJingfang GaoMing TaoKerang ZhangChengge GaoLijun YangKan LiJianguo Shi
Early onset of mental disorders is a major social and public health concern as it affects individuals in their most formative years. The impact is more pronounced when early onset is also associated with treatment delay. Little is known about the age of onset (AOO) for mental disorders and ...
Because cumulative comorbidity between GAD and MDD was most marked in cohort members who experienced recurrent disorder (Figure 5), we repeated the analyses of sequential order, limiting the cases to those having diagnoses at 2 or more assessments (Figure 7). Among cohort members with recurrent MD...
DAVID Functional Annotation Clustering Tool confirmed that the most enriched gene cluster in the BDNF coexpression network included synapse- related genes (enrichment score = 6.93). The second and third clusters identified by DAVID analysis were also associated with synapse (Figure 1d and Supplementary...
(Pvalue = 1.12 × 10−2) showed such enrichment in astrocytes, the most prevalent glial cells in the brain. GM-BAG showed no enrichment in any of these cells. Our findings are consistent with understanding the molecular and biological characteristics of GM and WM. Oligodendrocytes ...
The current sample was highly educated, and most mothers were married or living common law. Although this might limit the confounding effects of family stress on the study results, the current findings may not translate to more vulnerable populations. As is the case with many large pregnancy ...
Specifically, 1:1 matching would pair each older adult with only the single most similar working-age counterpart, thereby disregarding numerous other potentially comparable individuals. For example, only 66 (0.8 %) working-age adults would be selected as the comparison group for old-old adults (...
Undernutrition remains the world’s most serious health problem and a major contributor to child mortality [1]. Child undernutrition is responsible for > 50.0% of all childhood deaths [2]. Globally, it is estimated that, 25.6% of children < 5 years of age are stunted with prevalence ...
Keeping neurons in an excitable state is most effectively achieved by fluctuating the membrane potential close to the action potential threshold. In principle, this can be achieved by “noise,” sustained by balanced inhibitory and excitatory inputs. In line with this reasoning, improvement of behavi...
The most explicit link is with emotion-focused coping as it provides tools directly designed to manage stress-related emotions37–39. Furthermore, reappraisal (as one of the ER strategies) may, for example, help change the emotional perception of a stressful situation into a positive, less ...