genomic instability, epigenetic alterations, cellular senescence and mitochondrial dysfunction, leading to deterioration in function [1]. It is one of the leading risk factors for many chronic diseases such as type 2 diabetes, cardiovascular disease, dementia, and cancer [2,3]. ...
performance IQ76. On the other hand, schizophrenia is a highly heritable mental disorder that exhibits functional dysconnectivity throughout the brain77. AD was causally associated with FC-BAG with nominal significance [risk effect for per unit increase;Pvalue = 4.43 × 10−2, OR (9...
Sex was defined on the basis of self-report. Participants were classified as having hypertension if the systolic blood pressure was ≥140 mm Hg or the diastolic blood pressure was ≥90 mm Hg at any clinic visit or exam antecedent to DNA collection, or if the participant was receiving treatm...
In contrast to the ADI-R and the PL-ADOS, Figure 1 shows that clinicians rarely (2 in 172 cases or 1%) classified children as having autism who had not been classified in the same way by 1 of the other measures. On the other hand, clinicians relatively frequently (26 in 172 cases or...
, and education (all positively). ACE and NLE have a highly significant impact on the DSOA score and are not associated with aMCI or its severity. Cluster analysis showed that the diagnosis of aMCI is overinclusive because some subjects with DSOA symptoms may be incorrectly classified as aMCI....
Donors were classified as seropositive or seronegative using the thresholds recommended by the manufacturer (Additional file 1: Table S2). The vast majority of the 1000 healthy donors were chronically infected with EBV (seropositivity rates of 96% for EBV VCA, 91% for EBV EBNA, and 9% for ...
Birthweight was classified into two categories: Low PLOS ONE | DOI:10.1371/journal.pone.0146241 January 21, 2016 2/9 Maternal Smoking and Birthweight by Maternal Age birthweight (<2500 g) and not low birthweight (2500 g). Other information investigated included: maternal ...
Perivascular spaces can be classified according to the location of blood vessels, as well as according to morphology. The two most common types are the single follicle type that is an isolated and round-like cystic structure and the local cluster type constituted by multiple strips and lines. ...
The functional impact of missense germline variants was predicted using MetaSVM ensemble algorithm28 and annotation by ClinVar database when available31. We considered a missense variant high-functional impact if classified as Deleterious by MetaSVM or listed as Pathogenic/Likely-Pathogenic in ClinVar....
This threshold-based approach resulted in 12 and 16 individuals being classified as early and late onset, respectively, for MCI. We filtered the observed genetic variants by their frequency among early- and late-onset individuals, requiring the presence of a variant in at least four individuals ...