Although ferroptosis was discovered as a form of cell death 10 years ago, ferroptosis-like cell death had been described for a very long time; for example, “oxytosis” was coined described cell death caused by oxidative stress.40,41From the 1950s and later, Harry Eagle’s pioneering work ...
F. Mitochondrial disease in adults: what’s old and what’s new? EMBO Mol. Med. 7, 1503–1512 (2015). Article CAS PubMed PubMed Central Google Scholar Gonzalez-Freire, M. et al. The road ahead for health and lifespan interventions. Ageing Res. Rev. 59, 101037 (2020). Article ...
But by 2014, the death rate from Alzheimer’s Disease for thisagegroup have more than doubled, increasing from 3.8% to 8.5%, making the progressive brain disease the second leading cause of death for centenarians. 出自-2016年12月听力原文 ...
There are two types of macular degeneration: wet and dry. Most people with macular degeneration have the dry form, but in its advanced stages, dry AMD can lead to the wet form of the disease. Wet vs. dry macular degeneration Wet and dry AMD have distinct differences. ...
Age is the predominant risk factor for cognitive decline. Whilst some decline in cognition is considered an inevitable part of healthy ageing, deleterious changes in cognition, including mild cognitive impairment (MCI) and age-related dementias (e.g., Alzheimer’s disease, AD), are estimated to ...
and this vascularization was closely related to age and disease course. Angiogenesis may be a repair process following disc injury and may contribute to tissue degeneration.182Notably, the hemoglobin signal was found to be significantly increased in herniated NPs compared with nonherniated NPs, and mo...
Full size image Table 2 Changes in the level of expression of members of the fibroblast growth factor (FGF) family in disease Full size table FGF2 Similar to the effect of FGF2 on chondrocytes in OA, the role of FGF2 in IVDs and the pathogenesis of IVDD remains a subject of controversy...
“Measuring body mass”) is a public health problem because it is associated with premature death and is arisk factorforcoronary heart disease, diabetes mellitus, hypertension, asthma,gastrointestinal disorders, and cancer. While there is evidence of agenetic predispositionfor obesity, diet and other...
The Random Forest (RF) was used to identify patients with Parkinson’s disease with time-domain and frequency-domain gait features to obtain 98.04% accuracy27. In recent studies, several machine learning methods have been employed for classifying fallers and non-fallers with a functional test (...
Full size image Table 1 Lung sample clusters related to disease. Full size table Discussion Using the GTEx dataset, we have curated a body-wide understanding of the transcriptomic matrisome in health and limited disease states. The large dataset of GTEx, and others like it, may improve our col...