We tested the hypothesis that the pathogenesis of DR can be reduced by the classic EGFR inhibitor, AG1478, in the mouse models. Our data indicated that treatment of AG1478 prevented retinal dysfunction, and reduced impairment of retinal structures as well as mitochondrial structures in retinal blood...
Constitutive activation of the PI3K/Akt pathway by the lack of PTEN regulation is associated with resistance to novel targeted therapies including EGFR inhibitors. We aimed to study whether Ly294002, an inhibitor of PI3K, could enhance the ...
A specific epidermal growth factor receptor (EGFR) inhibitor AG1478 was used to examine the relationship between EGFR signal pathways and oridonin-induced apoptosis and autophagy in EGFR abundant human epidermoid carcinoma A431 cells. Inhibition of EGFRaugmented oridonin-induced A431 cell apoptosis, ...
Baba, Y.; Maeda, T.; Suzuki, A.; Takada, S.; Fujii, M.; Kato, Y. Deguelin potentiates apoptotic activity of an egfr tyrosine kinase inhibitor (AG1478) in PIK3CA-mutated head and neck squamous cell ...
Objective: To investigate the effects and molecular mechanisms of esomeprazole combined with epidermal growth factor receptor (EGFR) inhibitor AG1478 on proliferation, migration, apoptosis and autophagy of gastric cancer cells. Methods: The experiment was divided into blank...
Johns, The epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor AG1478 increases the formation of inactive untethered EGFR dimers, J. Biol. Chem. 282 (2007) 2840-2850.Gan HK, Walker F, Burgess AW, Rigopoulos A, Scott AM and Johns TG (2007) The epidermal growth factor receptor...
Objective To observe the effect of epidermal growth factor receptor (EGFR) inhibitor AG1478 combined with endocrine therapy on growth of breast carcinoma xenografts in nude mice. Methods Breast carcinoma nud mice model was created by using MCF-7 breast cancer cells. The mice were divided into 4 ...
New platform for controlled and sustained delivery of the EGF receptor tyrosine kinase inhibitor AG1478 using poly(lactic-co-glycolic acid) microspheres.Epidermal growth factor receptortyrosine kinase inhibitorsAG1478microspheresPLGAInhibition of the epidermal growth factor receptor (EGFR) reduces tumour growth...
Inhibition of EGFR-Grb2 interaction by the small tyrosine kinase inhibitor AG1478.Peter LanzerstorferDaniela BorgmannGerhard SchützStephan M. WinklerOtmar HöglingerJulian Weghuber
AG1478 is a specific epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor. The effect of AG1478 on the A549/DDP (cisplatin-resistant human lung adenocarcinoma) cell line is unknown. The aim of the present study was to investigate the effects of AG1478 on the A549/DDP cell line ...