Pembrolizumab carries a risk of serious, sometimes fatal, adverse effects. Kidney cancers are most often renal cell carcinomas, most of which are ofthe clear cell type. One-third of patients presenting with local disease also have regional or distant metastases. First-choice treatment is then ...
Although there is no direct drug interaction between prednisone and alcohol, mixing them together is not a good idea because some of the effects of alcohol and the side effects of prednisone are similar, so taking both at the same time can increase the risk of these side effects occurring. ...
Results from a large clinical trial show that treatment with an immunotherapy drug may nearly double the length of time people with high-risk, muscle-invasive bladder cancer are cancer-free following surgical removal of the bladder. Researchers found that postsurgical treatment with pembrolizumab (Keyt...
As the development of personalized cancer vaccines should be developed as soon as possible, we aimed to manufacture a vaccine within 45 days of initial treatment and allow patients to receive the vaccine in combination with their third dose of Keytruda. Such experience in developing customized cancer...
s Keytruda and Merck KGaA’s Bavencio. In a twist, the FDA nod came as a surprise to industry watchers because Incyte hadn’t announced its application filing or a decision date before the official word came down, analysts with William Blair pointed out. At the time of the ...
an aggressive form of the disease that disproportionately affects Black women and has long been difficult to treat. One type of immunotherapy, pembrolizumab (Keytruda), has been effective when used alongside chemotherapy and it has now become the standard of care to treat certain types of triple-...
The predicted probability of 2-year survival was calculated using a mixed-effects logit model adjusting for demographic and clinical characteristics. Results The study sample included 53 719 patients (mean [SD] age, 68.5 [9.3] years; 28 374 men [52.8%]), the majority of whom were White ...
“The patients were previously untreated, biopsy-confirmed, operable stage 2 or 3B NSCLC, which is a very good candidate for this treatment,” Cho said. “The study was a head-to-head comparison of the combination of Keytruda and conventional chemotherapy vs. a placebo without Keytruda but wit...
Therefore, the combined effects and mechanisms of SMI and programmed death-1 (PD-1) inhibitor against NSCLC was focused on this study. Methods A Lewis lung carcinoma mouse model and a lung squamous cell carcinoma humanized mouse model were used to investigate the combined efficacy and safety of...
The drugs under review this week—Merck's Keytruda, Roche's Tecentriq and Bristol Myers Squibb's Opdivo—are part of a recent wave of "immunotherapies" that help the body's defense system recognize and attack cancer. The blockbuster drugs have shown life-extending gains against deadly forms of...