引言:产AFP胃癌(AFP producing gastric cancer, AFPGC)是一类罕见但高度恶性的胃癌亚型,常早期发生转移和原发耐药,预后较差。其主要特征是血清AFP水平升高(通常大于20ng/mL)。目前,AFPGC的病理发生机制尚未被充分认识,且缺乏有效的治疗手段。Dickkopf-1(DKK1)是经典WNT信号通路抑制基因,既往研究表明,DKK1在各类肿瘤中...
15.Ota T, Sakashita K, Sawada R, et al.15. Long-term survival with nivolumab followed by irinotecan after total gastrectomy in alpha-fetoprotein-producing gastric cancer: a case report and review of the literature. ...
Alpha-fetoprotein-producing gastric cancer(AFP-GC) is a relatively rare disease, accounting for 1.3–15% cases of gastric cancer [1, 2]. AFP-GC is associated with poor prognosis because of high rates of liver and lymph node metastases [3, 4]...
This study aimed to investigate whether 伪-fetoprotein (AFP) could affect the malignant behavior of AFP-producing gastric cancer (AFP-GC) and to explore the relationship between AFP and mesenchymal鈥揺pithelial transition factor (c-Met) in AFP-GC. In this study, 23 patients with AFP-GC (...
Suguru Maruyama;Shinji Furuya;Kensuke Shiraishi;Hiroki Shimizu;Hidenori Akaike;Naohiro Hosomura;Yoshihiko Kawaguchi;Hidetake Amemiya;Hiromichi Kawaida;Makoto Sudo;Shingo Inoue;Hiroshi Kono;Daisuke Ichikawa.miR-122-5p as a novel biomarker for alpha-fetoproteinproducing gastric cancer.World Journal of Gastroint...
[7]Shibata Y,Sato K,Kodama M,Nanjyo H.Alpha-fetoprotein-producing early gastric cancer of the remnant stomach:report of a case.Surg Today.2007,37:995-999. [8]刘伟,张丽虹,曲玉清,等.卵巢混合性生殖细胞肿瘤病理特征 及诊断分析[J].中国临床新医学,2020,13(10):1031-1035. ...
Background:Alpha-feto protein-producing gastric cancer (AFP-GC) is a relatively rare disease, with a dismal prognosis. 摘要 背景:产生AFP的胃癌是一少见疾病,且预后不佳。 Case presentation: We report the case of a patient with long-term survival after surgery for the recurrence of AFP-GC. A...
是Bourrielle等[1]于1970年报道首例AFP阳性胃癌(alpha-fetoprotein—producing gastric carcinoma'AFPGC)。有关AFPGC的文献报道主要来自日本 。APGC发病率国外文献统计占胃癌的5.1 ～15%,国内报道发病率比国外低[2]。现将我院2008年1月～8月发现的2例AFP阳性胃癌结合国内外文献复习报道如下。
Suguru Maruyama;Shinji Furuya;Kensuke Shiraishi;Hiroki Shimizu;Hidenori Akaike;Naohiro Hosomura;Yoshihiko Kawaguchi;Hidetake Amemiya;Hiromichi Kawaida;Makoto Sudo;Shingo Inoue;Hiroshi Kono;Daisuke Ichikawa.miR-122-5p as a novel biomarker for alpha-fetoproteinproducing gastriccancer.World Journal of Gastrointes...
针对AFPGC患者，早期发现尽早外科干预很重要。参考文献：Akabane M, Yago A, Haruta S, Ohkura Y, Ueno M, Udagawa H: Re-evaluation of the prognosis of alpha-fetoprotein-producing gastric cancer from a single center: a case series study. Langenbeck's archives of surgery 2023, 408(1):66.