The biotransformation of AFB1 generates the adducts AFB1-N7-guanine and AFB1-lysine, which are used as biomarkers of human exposure to dietary AFB1 in epidemiological studies. This article presents a review of main studies on the use of AFB1 adducts as biomarkers of human exposure to AFB1, and...
[7] Hazra TK,Hill JW,Izumi T,et al. Multiple DNA glycosylases for repair of 8-oxoguanine and their potential in vivo functions[J]. Prog Nucleic Acid Res Mol Biol,2001,68:193-205. [8] Noguchi N,Watanabe A,Shi H. Diverse functions of antioxidants[J]. Free Radic Res,2000,33(6):80...
血清AFs白蛋白加合物和尿黄曲霉B1-N7-鸟嘌呤(aflatoxin-B1-N7-guanine, AFB1-N7-GUA)加合物是人群AFs内暴露的经典标志物,被广泛用于流行病学研究。AFs作用的靶器官主要为肝脏,1993年国际癌症研究署将AFs确定为Ⅰ类人类致癌物,是科学家较早确立的肝癌病因,随着HBV感染与肝癌发生相关性的建立,Ross等通过分析...
Novel adenine adducts, N7-guanine-AFB1 ad‐ ducts, and p53 mutations in patients with schistosomiasis and aflatoxin exposure. Cancer Detect Prev, 2006; 30(6): 491-498.Habib SL,Said B,Awad AT,et al.Novel adenine adducts,N7-guanine-AFB1adducts,and p53 mutations in patients with ...
The cytochrome P450 activates AF as an unstable molecule called 8,9 AFB1 epoxide, that binds mainly to the N7 of the guanine nucleotide forming adducts that are the active carcinogens themselves and, as biomarkers, an objective measure of human exposure to environmental carcinogens. Adducts ...
A0A4X1UZS2 Guanine nucleotide-binding protein subunit gamma 0.8272 0.0023 down A0A8D1AC24 BAF chromatin remodeling complex subunit BCL11A 0.8175 0.0076 down A0A8D0IDB5 Centromere protein T 0.7350 0.0139 down A5D9L5 Chromosome 7 open reading frame human C6orf47 0.7744 0.0018 down A0A4X1VG85 DCN1...