AF64A(ethylcholine mustard aziridinium ion,ECMA)是一种特异性胆碱能神经毒素.在成年雄性大鼠双侧侧脑室(ICV)注射AF64A溶液(1.5nmol/侧,n=10),一个月后,应用NADPH-黄递酶(NADPH-d)组化染色结合胆碱乙酰基转移酶(ChAT)免疫细胞化学双标记法检测AF64A对隔复合体各细胞亚群内的一氧化氮合酶(NOS)和乙酰胆碱(ACh...
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AF64A (ethylcholine aziridinium) has generated considerable interest following the demonstration by Fisher and colleagues, in 1980 (1, 2), that it can induce a persistent central cholinergic hypofunctionin vivo. A variety of studies have since been conducted using this compound, in several laborat...
The time course of the cholinotoxicity of ethylcholine aziridinium ion (AF64A) has been investigated. Rats were injected with AF64A (3 nmols/3 渭1/side, bilateral, i.e.v.) or with vehicle. One day to one year after treatment, the hippocampus, cortex and striatum were analyzed for ...
Animals treated with AF64A made fewer correct responses in their first 8 choices, required more total selections to complete the task, and had an altered pattern of spatial responding in the maze. The neurochemical changes produced by AF64A, determined 120 days after dosing, were specific to ...
The focus of this chapter is on how two specific neurotoxins, AF64A (ethylcholine mustard aziridinium) and 192-IgG-saporin, have been used to study aspects of AD. The behavioral effects of these compounds have been reviewed elsewhere (Walsh et al., 1994; 1996). Both of these compounds ...
瞄准:由老鼠在有害的热刺激并且在导致吗啡的 antinociception 的效果在原子核缝妈牛羚(NRM ) 检验胆碱能的神经原的角色.方法:在胆碱能的神经原以后选择毒素, AF64A,是微的注入了 NRM,我们在 antinociceptive 阀值和吗啡的效果检验了变化(5 mg/kg, ip ) 用热板(HP ) 并且尾巴轻打(TF ) 测试.结果:吗啡的全...
Microinjection of AF64A (2 nmol/site) into the NRM significantly decreased the threshold of HP response after 14 d, whereas the TF response was not affected. Mor-phine-induced antinociception was significantly attenuated in rats administered AF64A. Extracellular acetylcholine was attenuated after 14...
中文名称:AF-64A-P 中文同义词: 英文名称:AF-64A-P 英文同义词:AF-64A-P CAS号:63918-38-7 分子式:C12H16N4O10S 分子量:408.34124 EINECS号: Mol文件:63918-38-7.mol 63918-38-7 信息错误报告 提交 按省份浏览63918-38-7供应商 国外供应商 ...
(1995). Failure of the Neurotrophic ACTH(4–10) Analogue (BIM 22015) to Attenuate the AF64A-Induced Cholinergic Lesion in Rat Hippocampus. In: Hanin, I., Yoshida, M., Fisher, A. (eds) Alzheimer’s and Parkinson’s Diseases. Advances in Behavioral Biology, vol 44. Springer, Boston, MA...