Cancer cells depend on glucose metabolism via exclusive glycolysis pathway is named Aerobic glycolysis or Warburg effect. The aim of this study was investigation of different glucose accessibility conditions on the rate of Warburg effect and its impact on Hypoxia inducible factors-1 α (HIF-1 α)/...
Aerobic Glycolysis Is Activated in Immune Cells via the Akt-mTORC1-HIF Pathway Aerobic glycolysisin activated macrophages and dendritic cells occurs uponligand bindingof various toll-like receptors (TLR), includingTLR2,29,30TLR3,29TLR4,29–31TLR7/829andTLR9.29,30It has also been reported in macr...
Mechanistically, we found that E6/E7 proteins regulate the activity of key enzymes in the aerobic glycolysis pathway by affecting the binding of IGF2BP2 to MYC m6A sites. We further established that the overexpression of IGF2BP2 in E6/E7-knockout CC cells rescued glycolytic flux. Combined, ...
It has been reported that cancer cells utilize this glycolysis pathway even in the presence of adequate oxygen to provide cancer cells with energy, called the Warburg effect (aerobic glycolysis). Myc is known to regulate LDH and pyruvate dehydrogenase kinase 1 (PDK1), which are master regulators...
Fasting inhibits aerobic glycolysis and proliferation in colorectal cancer via the Fdft1-mediated AKT/mTOR/HIF1α pathway suppression Mei-lin Weng, Wan-kun Chen, Xiang-yuan Chen, Hong Lu, Zhi-rong Sun, Qi Yu, Peng-fei Sun, Ya-jun Xu, Min-min Zhu, Nan Jiang, Jin Zhang,...
Aerobic glycolysis is a phenomenon by which malignant cells preferentially metabolize glucose through the glycolytic pathway, rather than oxidative phosphorylation to proliferate efficiently. The present study aimed to investigate the expression and functional implications of long non-coding (lnc)RNA Ftx in...
LX-2 cells showed diminished migration, proliferation, and aerobic glycolysis after PF562271 intervention. FAK promotes aerobic glycolysis in LX-2 cells through the cyclin D1/c-Myc/MCT-1 pathway, thereby increasing liver fibrosis.Nature Publishing Group UKScientific ReportsTao Huanghttps://ror.org/...
found that the upregulation of the aerobic glycolysis pathway contributes to the acquired resistance of sorafenib in HCC [23, 24]. The findings of our study have provided evidence for the association between EGR1 downregulation and the induction of aerobic glycolysis. In order to explore the ...
Aerobic glycolysis was firstly found in HCC, acts as a hallmark of liver cancer and is responsible for the regulation of proliferation, immune evasion, invasion, metastasis, angiogenesis, and drug resistance in HCC. The three rate-limiting enzymes in the glycolytic pathway, including hexokinase 2 ...
In turn, this increased dependence on glycolysis rendered m.12,43660% (half-maximum inhibitory concentration, IC50 = 0.81 ± 0.064 mM) and m.11,94460% cells (IC50 = 1.04 ±0.040 mM) more sensitive to the competitive phosphoglucoisomerase inhibitor 2-deoxyglucose ...