在ACC/JACC最新临床试验联合会场上,来自美国马萨诸塞州波士顿哈佛医学院的C.Michael Gibson教授公布了AEGIS-II试验的主要结果,研究结果发现:与安慰剂相比,接受CSL-112输注治疗患者的心血管死亡、1型心肌梗死和支架血栓相关心肌梗死的复...
AEGIS-II将是第一项正式检验加强胆固醇流出是否能降低主要CV不良事件复发率的试验。2024年2月11日,澳大利亚制药商CSL公司公布了CSL112 Ⅲ期试验AEGIS-II的主要结果:未达到降低急性心肌梗死(AMI)后患者主要不良心血管事件(MACE)风险的...
鉴于其对稳定斑块的预期效果,AEGIS-II最初旨在评估CSL-112对心血管死亡、1型MI或卒中的复合事件的影响,但由于总体事件发生率低于预期,因此对主要终点进行了修正,纳入所有MI类型。在这项 AEGIS-II试验的探索性分析中,我们将重点评估CSL-112治疗对CV死亡和复发性MI亚型发生率的影响,重点关注1型MI。 研究方法 ACC.24...
Global biotechnology leader CSL announced top-line results from the Phase 3 AEGIS-II trial evaluating the efficacy and safety of CSL112 compared to placebo in reducing the risk of major adverse cardiovascular events in patients following an ac...
High-density lipoprotein (HDL) is integral to reverse cholesterol transport (RCT), a process considered to protect against atherosclerotic cardiovascular disease (ASCVD). We summarise findings from the recent AEGIS-II trial and discuss new opportunities for HDL therapeutics targeted at RCT.Mendelian ...
Spatial repellents (SRs) have been widely used for prevention of mosquito bites, but their efficacy in reducing Aedes-borne viruses (ABV) has not been tested rigorously at large scale in Asia. To address this knowledge gap, a trial to evaluate the effica
When using a continuous live training approach for the ANN, the trial solutions suggested by the optimiser will be classified by the ANN as valid or invalid. The continuous live training of the ANN was performed in parallel with the evaluation of the objective function by the Interface-AVL. Wi...
The main idea is to focus all the computational efforts on the worthwhile solutions, rather than exploring and evaluating all trial solutions in the design space [5]. ML is a field of computer science that gives the computer the ability to "learn" without being explicitly programmed. The term...
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