Intravenous acetylcysteine is used for the management of paracetamol overdose worldwide. Recently, there has been increasing recognition of its adverse effects. This article reviews the features of these reactions, the factors that affect their frequency, and ways to reduce their frequency and severi...
Nausea was the most common adverse reaction. The rate of non-allergic anaphylactoid reactions with the one-bag protocol was 4%.doi:10.1080/24734306.2020.1770498Michael E. MullinsMary YuLauren O'GradyShariq KhanEvan S. Schwarz
108 Analgesics Anti-inflammatory Drugs and Antipyretics Paracetamol (BAN, rINN) Acetaminofeno; Acetaminophen; N-Acetyl-p-aminophenol; Asetaminofen; Paracétamol; Paracetamolis; Paracetamolum; Par- asetamol; Parasetamoli. 4′-Hydroxyacetanilide; N-(4-Hydroxy- phenyl)acetamide. Парацетам...
drug hypersensitivity reactionover-the-counter drugsadverse eventsdrug safetyspontaneous reportingParacetamol is a popular and easily available drug which is used world-wide as analgesic, antipyretic agent. Hypersensitivity reactions to this drug involve a wide range of symptoms of various importance for ...
3. The Adverse Drug Reaction Problem Preventable ADRs have proved an intractable problem over the last decade, causing 5–8% of unplanned UK hospital admissions [30,31], rising to ~10% amongst older adults [32], and costing the NHS £1 bn–£2.5 bn each year [33]. ADRs assessed ...
An adverse drug reaction (ADR) is defined by the World Health Organization as “a response to a drug which is noxious and unintended, and which occurs at doses normally used in man for the prophylaxis, diagnosis, or therapy of disease, or for the modifications of physiologic function.” ...
The precise nature of this reaction remains unclear. Histamine now seems to be an important mediator of the response, and there is evidence of variability in patient susceptibility, with females, and those with a history of asthma or atopy are particularly susceptible. Quantity of paracetamol ...
Identify as rapidly as possible the drug inducing the reaction and always opt for its withdrawal; in some circumstances the choice is difficult as there is no alternative drug and its use is essential for the maintenance of life; 1 A careful and intensive observation is recommended for the occu...
The solidity of the evidence base depends on the frequency of the reaction, and causality is not always easy to establish for the very rare adverse reactions. Drug–drug interactions are rare. Osteoporosis treatments are generally safe and well tolerated, though they are associated with a few ...
Objective To explore the characteristics of the adverse drug reaction( ADR) in The Second People's Hospital and to promote rational drug use. Methods Five hundred and eighty-one cases of ADR reported in 2012-2013 were statistically analyzed. Results Of 581 cases of ADR reports,there were 290 ...