Learn how PMI’s research on adverse outcome pathways (AOPs) can improve toxicology and risk assessment, and how they support the tobacco harm reduction approach.
有害结局路径152-154 Curtain Road, Shoreditch (EC2A 3AT (Adverse Outcome Pathway,AOP) -21世纪的毒理学测试策略 21世纪毒性测试中国公益项目 2016年6月21日 21世纪毒性测试体系产生背景 药品: • 2004年,开发和测试一个新药的平均成本是 9亿美元.到了2008 年最低估计为13.94亿美元.开发一个新药到上市...
152-154 Curtain Road, Shoreditch (EC2A 3AT 有害结局路径 (Adverse Outcome Pathway ,AOP) -21世纪的毒理学测试策略 21世纪毒性测试中国公益项目 2016年6月21 日 21世纪毒性测试体系产生背景 药品: • 2004年,开发和测试一个新药的平均成本是 9亿美元。到了2008 年最低估计为13.94亿美元。开发一个新药到...
The role of chemistry in developing understanding of adverse outcome pathways and their application in risk assessment The Adverse Outcome Pathway (AOP) conceptual framework has been presented as a logical sequence of events or processes within biological systems which can ... G Steve,R Paul - 《...
The pathways involved have recently been formally described in the OECD adverse outcome pathway (AOP) for skin sensitization. One single non-animal test ... D Urbisch,A Mehling,K Guth,... - 《Regul Toxicol Pharmacol》 被引量: 106发表: 2015年 Assessing skin sensitization in mice and men us...
Adverse outcome pathway (AOP) for human health risk assessment Marescotti, D. Conference date Jun 16, 2022 Conference name Global Forum on Nicotine (GFN) 2022 Topic Summary Watch Diego Marescotti's 5-minute presentation for GFN 2022.
Adverse Outcome Pathway (AOP) Integrated Approaches to Testing and Assessment (IATA) (Q)SAR Read-across High throughput screening (HTS) High content screening (HCS) Cross species extrapolation 1. Introduction 1.1. AOPs to support IATA in regulatory decision-making Within the last decade, the global...
A major step in this direction came with the introduction of the mode of action concept, which relates to a series of key events along a biological pathway from the initial chemical interaction to the adverse outcome (OECD, 2012a). The mode of action concept was originally used by the US ...
In parallel, the development of the Adverse Outcome Pathway (AOP) framework, which provides information on the causal links between a molecular initiating event (MIE), intermediate key events (KEs) and an adverse outcome (AO) of regulatory concern, offers the biological context to facilitate ...
Potential adverse outcome pathway (AOP) of silver nanoparticlesmediated reproductive toxicity in zebraf i shYan-Bo Maa , Chun-Jiao Lu a , Muhammad Junaid a , b , Pan-Pan Jia a , b , Li Yang a ,Jing-Hui Zhanga , De-Sheng Pei a , *a Key Laboratory of Reservoir Aquatic Environment,...