Adverse-drug-reactions-incidenceCNS-disorders, drug-inducedDrug-overdoseHeart-disorders, drug-inducedRespiratory-tract-disorders, drug-inducedTramadol, overdoseReactions Weekly -doi:10.2165/00128415-199706620-00009NoneSpringer International PublishingReactions Weekly...
3 and blood transfusions may be required in some patients.1-4 A study indicated that zidovudine-induced neu- tropenia only significantly increased the risk of bacterial infec- tion in patients whose polymorphonuclear cell count fell below 500/microlitre.6 The effects of zidovudine on the platelet...
Effects on the cardiovascular system. For a discussion of the possible cardiovascular effects of naproxen, see p.96. Naproxen 93 Effects on the CNS. Aseptic meningitis has been associated with naproxen therapy;1,2 attacks may be recurrent and cross- sensitivity with other NSAIDs has occurred.2 ...
the endpoint of titration is achievement of adequate pain relief, balanced against tolerability of opioid side effects; if a patient develops intolerable opioid related side effects, the methadone dose, or dosing interval, may need to be decreased; for patients on a regimen of fixed-ratio opioid/...
Adverse drug reactions are a common clinical problem and are associated with significant risk of morbidity, mortality and admission to hospital. It is an undesirable effect of a drug beyond its anticipated therapeutic effects occurring during clinical use. The objective of the study was to assess in...
Doing so can destroy the long action of the drug and may increase side effects.The dosage is based on your medical condition and response to treatment. Your doctor will adjust the dose to find the best dose for you. Use this medication regularly and exactly as prescribed in order to get ...
Reporting rate of adverse drug reactions to the French pharmaco- vigilance system with three step 2 analgesic drugs: dextropropoxy- phene, tramadol and ... Neda,Tavassoli,Maryse,... - 《British Journal of Clinical Pharmacology》 被引量: 35发表: 2009年 REPORTING AND MONITORING OF ADVERSE DRUG ...
Comparison of buprenorphine and methadone effects on opiate self-administration in primates. The effects of ascending and descending doses of buprenorphine (0.014-0.789 mg/kg/day) and methadone (0.179-11.86 mg/kg/day) on opiate and food intake were studied in Macaque monkeys over 195 to 245 ...
Effects of the CYP2D6 gene duplication on the pharmacokinetics and pharmacodynamics of tramadol. The analgesic drug tramadol is bioactivated by CYP2D6 to the opioid receptor agonist O-desmethyltramadol. Case reports indicated that carriers of the CYP2D... J Kirchheiner,JTHA Keulen,S Bauer,... -...
Therapy exposes users to the risks of addiction, abuse and misuse; because extended-release products deliver opioid over extended period of time, there is a greater risk for overdose and death due to the larger amount of tramadol present; addiction can occur at recommended dosages and if drug ...